Cejkova J., Labsky J., Vacik J.:
CONTACT AND INTRAOCULAR LENSES CONTAINING ULTRAVIOLET ABSORBERS AND METHOD OF THEIR PRODUCTION
PCT/ CZ 96 / 00016 June 11, 1996
The full text of the patent is available here.
Cejkova J., Labsky J., Vacik J.:
PREVENTION OF THE EYE AGAINST THE DAMAGING EFFECT OF UV RAYS BY SOFT CONTACT-LENSES WITH UV ABSORBERS
VISION RES 35: P153-P153 Suppl. S OCT 1995
Labsky J., Vacik J., Cejkova J. (CORPORATE SOURCE Ustav Makromolekularni Chemie AV CR; Ustav Ex Mediciny AV CR, Czech Rep.). SOURCE Czech Rep. CZ 284103 B6 12 Aug 1998, 7 pp. (Czech). (Czech Republic).
MANUFACTURE OF POLYMERIZABLE BENZOPHENONE DERIVATIVES AS UV ABSORBERS for CONTACT AND INTRAOCULAR LENSES
Chemical abstracts: 130:297084
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The title compds. [I; R = OH, NH2, NR12, C1-4 alkyloxy, phenoxy, (meth)acryloyloxyalkoxy, 3-methacryloyloxy-2-hydroxypropyloxy, etc.; R1 = Me, Et; R2 = H (when R1 = polymerizable group), (meth)acryloyl, (meth)acryloyloxyalkyl, etc.; R3 = C1-4 alkyl(oxy)], useful for the title purpose, were manufd. and claimed. I have increased soly. in monomer mixts. used for the manuf. of contact and intraocular lenses. Thus, adding dropwise over 10 min 0.011 mol methacryloyl chloride to a soln. of 0.01 mol 2,4-dihydroxy-2'-methoxycarbonylbenzophenone and 0.01 mol NaOH in 20 mL H2O and stirring the whole for 2 h gave a title deriv. I (R = MeO, R2 = CH2:CMeCO, R3 = H) (II) m. 66°. Hard contact lenses absorbing in the UV C range have been prepd. by radical polymn. for 24 h at 60° under N of 2-hydroxyethyl methacrylate contg. 0.3% ethylene glycol dimethacrylate, 0.025% azobis(2-methylpropionitrile) and 0.8-3% II. |
