Research topics
Our research program is focused on:
(1) Early events during proximal T cell signalling and the role of lipid rafts in temporal and spatial coordination of Lck and Fyn function
(2) The role of innate immune molecules in embryonic homeostasis
(3) The role of antimicrobial peptides in health and disease
Current Grant Support
GA AS CR (grant No. IAA500520707)
GA CR (310/09/2084)
Ministry of Education, Youth and Sports (grant No. 2B08066-4)
Ministry of Defense (grant No. 080188110R)
Most important recent papers
(2001-present; names of the lab members underlined)Filipp, D., Alizadeh-Khiavi, D., Richardson, C., Palma, A., Paredes, N., Takeuchi, O., Akira, S., Julius, M. H. 2001. Soluble CD14 enriched in colostrum and milk induces B cells growth and differentiation. Proc. Natl. Acad. Sci. USA 98: 603-608, 2001.
Filipp, D., Zhang, J., Leung, B. L., Shaw, A., Levin, S. D., Veillette, A., Julius, M.: Regulation of Fyn Trough Translocation of Activated Lck into Lipid Rafts. J. Exp. Med. 197: 1221, 2003.
Filipp, D., Leung, B. L., Zhang, J., Veillette, A., Julius, M.: Enrichment of Lck in Lipid Rafts Regulates Co-localized Fyn Activation and the Initiation of Proximal Signals Through TcR α Β J. Immunol. 172: 4266-4274, 2004.
Tribl, B., Filipp, D., Bödeker, H., Yu, P., Hammerrmüller, I., McKerlie, C., Keim, V., Sibbald. W.J.: Pseudomonas pneumonia mediated sepsis induces expression of Pancreatitis-associated protein-I in rat pancreas. Pancreas 29: 33-40, 2004.
Ljutic, B., Carlyle J.R., Nakagawa, R., Filipp, D., Julius, M., Zuniga-Pflucker J.C.: Functional Requirements for Signaling Through the Stimulatory and Inhibitory Mouse NKR-P1 (CD161) Natural Killer Cell Receptors. J. Immunol. 174: 4789-96, 2005.
Badour K., Mcgavin, M.K.H., Zhang, J., Freeman, S., Vieira, C., Filipp, D., Julius, M., Mills, G.B., Siminovitch, K.A.: Interaction of the Wiscott-Aldrich syndrome protein with sortin nexin 9 is required for CD28 endocytosis and cosignaling in T cells. Proc. Natl. Acad. Sci. USA 104: 1593-1598, 2007.
Filipp, D., Moemeni, B., Ferzoco, A., Kathirkamathamby, K., Zhang, J., Ballek, O., Davidson, D., Veillette, A., and Julius, M. Lck dependent Fyn activation requires c-terminus dependent targeting of kinase active Lck to lipid rafts. J. Biol. Chemistry 283: 26409-26422, 2008.
Reviews
Filipp, D., Julius, M.: Lipid Rafts: Resolution of "Fyn problem"? Mol. Immunol. 41: 645-656, 2004.
Other results - Patents
United States Patent Application Serial No.: 08/746883
Title: B CELL ACTIVATION
Inventors: Michael H. Julius, Dominik Filipp, Kamel-Alizadeh-Khiavi
Filed: November 18,1996
Issued: July 25, 2000
International Patent Application: PCT/CA 99/00482 Pub. No.: WO 9961468
International Filing Date: May 27, 1999
Title: THE INDUCTION OF ANTIBIOTIC PEPTIDES BY LAIT/sCD14 PROTEIN
Applicants: Gemma Biotechnology Ltd
Michael H. Julius, Dominik Filipp
Teaching, lectures, public presentations
Lecturer in Recent Advances in Immunology, Charles University, Prague.
Lecturer in Innate Immunity, Charles University, Prague.