Research topics
Genetics and genomics of the laboratory mouse. Gene expression at meiotic prophase. Male-limited hybrid sterility of mouse inter-specific hybrids. Segmental trisomy for proximal 30 Mb of Chromosome 17 as a mouse model of human aneuploidy syndromes. Mouse inter-species chromosome substitution strains as a tool for positional cloning of complex trait loci and for systems biology.
Current grant support
Ministry of Education, Youth and Sports of the Czech Republic (Center of Applied Genomics, grant No.: 1M68378050)
Grant Agency of the Czech Republic (grants Nos: GA301/07/1264, GA301/07/1383)
Praemium Academiae (2007-2012)
AnEUploidy: Integrated project, 6th Framework Program EC (grant No.: 037627)
Most important recent papers
(2004-present; names of the lab members underlined)Divina, P., Forejt, J.: The Mouse SAGE Site: database of public mouse SAGE libraries. Nucleic Acids Res. 32: D482-D483, 2004. (PubMed)
Trachtulec, Z., Vlcek, C., Mihola O., Forejt J.: Comparative analysis of the PDCD2-TBP-PSMB1 region in vertebrates. Gene 335: 151-157, 2004. (PubMed)
Storchova, R., Gregorova, S., Buckiova, D., Kyselova, V., Divina, P., Forejt, J.: Genetic analysis of X-linked hybrid sterility in the house mouse. Mamm. Genome 15: 515-524, 2004. (PubMed)
Auwerx, J., et al (including Forejt, J.).: The European dimension for the mouse genome mutagenesis program. Nat. Genet. 36: 925-7, 2004. (PubMed)
Churchill, G. et al. (including Forejt J.) Complex Trait Consortium.: The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat. Genet. 36: 1133-7, 2004. (PubMed)
Vacik, T., Ort, M., Gregorova, S., Strnad, P., Blatny, R., Conte, N., Bradley, A., Forejt, J.: Segmental trisomy of chromosome 17: a mouse model of human aneuploidy syndromes. Proc. Natl. Acad. Sci. USA 102: 4500-5, 2005. (PubMed)
Jansa, P., Divina, P., Forejt, J.: Construction and characterization of a genomic BAC library for the Mus m. musculus mouse subspecies (PWD/Ph inbred strain). BMC Genomics 6: 161, 2005. (PubMed)
Divina, P., Vlcek, C., Strnad, P., Paces, V., Forejt, J.: Global transcriptome analysis of the C57BL/6J mouse testis by SAGE: evidence for nonrandom gene order. BMC Genomics 6: 29, 2005. (PubMed)
Mihola, O., Forejt, J., Trachtulec, Z.: Conserved alternative and antisense transcripts at the programmed cell death 2 locus. BMC Genomics 8: 20, 2007. (PubMed)
Pialek, J., Vyskocilova, M., Bimova, B., Havelkova, D., Pialkova, J., Dufkova, P., Bencova, V., Dureje, L., Albrecht, T., Hauffe, H.C., Macholan, M., Munclinger, P., Storchova, R., Zajicova, A., Holan, V., Gregorova, S., Forejt, J.: Development of Unique House Mouse Resources Suitable for Evolutionary Studies of Speciation. J Hered 99: 34-44, 2008. (PubMed)
Homolka, D., Ivanek, R., Capkova, J., Jansa, P., Forejt, J.: Chromosomal rearrangement interferes with meiotic X chromosome inactivation. Genome Res 17: 1431-1437, 2007. (PubMed)
Gregorova, S., Divina, P., Storchova, R., Trachtulec, Z., Fotopulosova, V., Svenson, K.L., Donahue, L.R., Paigen, B., Forejt, J.: Mouse consomic strains: Exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies. Genome Res 18: 509-505, 2008. (PubMed) (Free full text)
Trachtulec, Z., Vlcek, C., Mihola, O., Gregorova, S., Fotopulosova, V., Forejt, J.: Fine Haplotype Structure of a Chrosome 17 Region in the Laboratory and Wild Mouse. Genetics 178: 1777-1784, 2008. (PubMed)
Mihola, O., Trachtulec, Z., Vlcek, C., Schimenti, J.C., Forejt, J: A mouse speciation gene encodes a meiotic Histone H3 methyltransferase. Science 323: 373-5, 2009. (PubMed)
Teaching, lectures, public presentations
MB140P57 - Molecular Genetics of Mammalian Organisms (semestral course, Charles University in Prague, Faculty of Science)