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Institute of Physiology ASCR, v.v.i.
Videnska 1083
CZ-14220 Prague 4
Czech Republic

Phone:     +420 24106 1111
                  +420 24447 2270
Fax:          +420 24106 2488

E-mail: fgubiomed.cas.cz

Achievements



Gastroenterology

Insight into circadian clock within the rat colonic epithelial cells.

The gastrointestinal tract exhibits diurnal rhythms in many physiological functions. The aim of the study was to provide evidence that the epithelial colonic cells are equipped with a molecular apparatus generating rhythmic signal with circadian, i.e., about daily, period and drive physiological processes within the cells. The data demonstrate that expression profiles of so called clock genes, i.e., genes indispensable for the core clock mechanism, namely Per1, Per2, Cry1, Bmal1, Clock a Rev-erbα, exhibit significant circadian rhythmicity within the colonic clock. Moreover, expression of electroneutral Na+/H+ exchanger seems to be directly driven by the molecular colonic clock and exhibits significant circadian rhythmicity. Molecular colonic clock is entrained not only by the master circadian clock located within the suprachiasmatic nuclei in the brain, but under specific conditions of restricted feeding, it is entrained dominantly by the timing of food availability.
Sládek M., Rybová M., Jindráková Z., Zemanová Z., Polidarová L., Mrnka L., O‘Neil J., Pácha J., Sumová A.: Insight into circadian clock within the rat colonic epithelial cells. Gastroenterology 133: 1240-1249, 2007 IF=12.457

Author: sumovabiomed.cas.cz
 




Review articles in prestige journal Nature Genetics
Identification of distribution and functional impact of DNA copy number variation in the rat

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Review articles in prestige journal Nature Genetics
Identification of osteoglycin (Ogn) as a genetic determinant predisposing to left ventricular hypertrophy in rats, mice, and humans

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Review articles in prestige journal Nature Genetics
Identification of single nucleotide polymorphisms and haplotype mapping in the rat

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Review articles in prestige journal Nature Genetics
Identification of renal Cd36 as a genetic determinant of blood pressure and risk for hypertension

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Journal article: Nature Genetics
Molecular-genetic basis of severe inherited mitochondrial disease – neonatal encephalo-cardiomyopathy.

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Article: Obesity
Chemical derivatives of docosahexaenoic acid (DHA) in the prevention and reversal of obesity in mice fed a high-fat diet

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Article: Diabetologia
n-3 fatty acids and rosiglitazone exerts additive effects on muscle glycogen synthesis in mice fed a high-fat diet

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Journal article: Proceedings of National Academy of Sciences of the USA
Risperidone and ritanserin but not haloperidol block effect of dizocilpine on the active allothetic place avoidance task

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Journal article: FASEB
In vivo content of mitochondrial ATP synthase is controlled by expression of the gene encoding hydrophobic subunit c.

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Review article: Oncogene
Current informations about the FOXO subgroup of forkhead transcription factors and mechanism of regulation

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Journal article: PLoS Computational Biology
Efficient coding principle confirmed for the sense of smell

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Journal article: Neurobiology of Aging
Evidence of impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mouse model of Alzheimer´s disease.

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Journal article: American Journal of Physiology Endocrinology and Metabolism
Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance

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Journal article: Journal of Pineal Research
The role of proline residues in the structure and function of human MT2 receptor.

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EBBS Award for Dr. Stuchlik
European Brain and Behaviour Society 40th Anniversary Award.

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Review article: Genome Research
Identification of a direct linkage of mitochondrial genome variation to risk factors for type 2 diabates in conplastic strains

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Journal of Biological Chemistry
N- terminal loop and wing W2- regions of forkhead domain are important for stability of the FoxO4-DBD-DNA complex.

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Journal article: Journal of Pharmacology and Experimental Therapeutics
Evidence of prolonged agonistic action of wash-resistantly bound M1 selective agonist xanomeline at M2 and M4 muscarinic receptor.

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Journal article: Journal of Pharmacology and Experimental Therapeutics
Evidence of the direct activation of Gq/11 and Gs G-proteins by agonist stimulation of the M2 muscarinic receptor.

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Journal article: Proceedings of National Academy of Sciences of the USA
Impaired hippocampal rhythmogenesis in a mouse model of mesial temporal lobe epilepsy.

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Journal article: Journal of Chromatography A
Study of posttranslational non-enzymatic modifications of collagen by CE–MS/MS, and HPLC–MS/MS

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