O ústavu Výzkum Studium Knihovna Časopis Aktuality Nabídka práce Hledání
English
Fotogalerie
Vstup do intranetu

Contact

Institute of Physiology ASCR, v.v.i.
Videnska 1083
CZ-14220 Prague 4
Czech Republic

Phone:     +420 24106 1111
                  +420 24447 2270
Fax:          +420 24106 2488

E-mail: fgubiomed.cas.cz

Achievements



Journal of Biological Chemistry

N- terminal loop and wing W2- regions of forkhead domain are important for stability of the FoxO4-DBD-DNA complex.

FoxO4 belongs to the "O" subset of forkhead transcription factors, which participate in various cellular processes. The forkhead DNA binding domain (DBD) consists of three-helix bundle resting on a small antiparallel beta-sheet from which two extended loops protrude and create two wing-like structures. In this report, we investigated the role of the N-terminal loop and the C-terminal region (loop known as wing W2) of the forkhead domain of transcription factor FoxO4 in DNA binding. Forster resonance energy transfer measurements and molecular dynamics simulations suggest that both studied N- and C-terminal regions of FoxO4-DBD directly interact with DNA. Our results show that both N- and C-terminal regions of forkhead domain are important for stability of the FoxO4-DBD-DNA complex.
Boura E, Silhan J, Herman P, Vecer J, Sulc M, Teisinger J, Obsilova V, Obsil T: Both the N-terminal loop and wing W2 of the forkhead domain of transcription factor FoxO4 are important for DNA binding. Journal of Biological Chemistry. 2007; 282(11): 8265-8275 IF=5,581.

Author: obsilovabiomed.cas.cz

 




Review articles in prestige journal Nature Genetics
Identification of distribution and functional impact of DNA copy number variation in the rat

zobrazitZobraz

Review articles in prestige journal Nature Genetics
Identification of osteoglycin (Ogn) as a genetic determinant predisposing to left ventricular hypertrophy in rats, mice, and humans

zobrazitZobraz

Review articles in prestige journal Nature Genetics
Identification of single nucleotide polymorphisms and haplotype mapping in the rat

zobrazitZobraz

Review articles in prestige journal Nature Genetics
Identification of renal Cd36 as a genetic determinant of blood pressure and risk for hypertension

zobrazitZobraz

Journal article: Nature Genetics
Molecular-genetic basis of severe inherited mitochondrial disease – neonatal encephalo-cardiomyopathy.

zobrazitZobraz

Article: Obesity
Chemical derivatives of docosahexaenoic acid (DHA) in the prevention and reversal of obesity in mice fed a high-fat diet

zobrazitZobraz

Article: Diabetologia
n-3 fatty acids and rosiglitazone exerts additive effects on muscle glycogen synthesis in mice fed a high-fat diet

zobrazitZobraz

Journal article: Proceedings of National Academy of Sciences of the USA
Risperidone and ritanserin but not haloperidol block effect of dizocilpine on the active allothetic place avoidance task

zobrazitZobraz

Journal article: FASEB
In vivo content of mitochondrial ATP synthase is controlled by expression of the gene encoding hydrophobic subunit c.

zobrazitZobraz

Review article: Oncogene
Current informations about the FOXO subgroup of forkhead transcription factors and mechanism of regulation

zobrazitZobraz

Journal article: PLoS Computational Biology
Efficient coding principle confirmed for the sense of smell

zobrazitZobraz

Journal article: Neurobiology of Aging
Evidence of impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mouse model of Alzheimer´s disease.

zobrazitZobraz

Journal article: American Journal of Physiology Endocrinology and Metabolism
Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance

zobrazitZobraz

Journal article: Journal of Pineal Research
The role of proline residues in the structure and function of human MT2 receptor.

zobrazitZobraz

EBBS Award for Dr. Stuchlik
European Brain and Behaviour Society 40th Anniversary Award.

zobrazitZobraz

Gastroenterology
Insight into circadian clock within the rat colonic epithelial cells.

zobrazitZobraz

Review article: Genome Research
Identification of a direct linkage of mitochondrial genome variation to risk factors for type 2 diabates in conplastic strains

zobrazitZobraz

Journal article: Journal of Pharmacology and Experimental Therapeutics
Evidence of prolonged agonistic action of wash-resistantly bound M1 selective agonist xanomeline at M2 and M4 muscarinic receptor.

zobrazitZobraz

Journal article: Journal of Pharmacology and Experimental Therapeutics
Evidence of the direct activation of Gq/11 and Gs G-proteins by agonist stimulation of the M2 muscarinic receptor.

zobrazitZobraz

Journal article: Proceedings of National Academy of Sciences of the USA
Impaired hippocampal rhythmogenesis in a mouse model of mesial temporal lobe epilepsy.

zobrazitZobraz

Journal article: Journal of Chromatography A
Study of posttranslational non-enzymatic modifications of collagen by CE–MS/MS, and HPLC–MS/MS

zobrazitZobraz

počítadlo.abz.cz