03.12.2008 - Review articles in prestige journal Nature Genetics

Identification of renal Cd36 as a genetic determinant of blood pressure and risk for hypertension

To search for quantitative trait loci (QTL) involved in the renal pathogenesis of essential hypertension, we integrated expression QTL analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy identified inherited variation in the renal expression of Cd36 encoding fatty acid translocase as a possible determinant of inherited variation in the risk for hypertension. In renal cross transplantation studies in SHR progenitor, transgenic, and congenic strains, selective genetic deficiency of wild type Cd36 in the kidney increased blood pressure, thereby establishing Cd36 in a novel renal gene pathway influencing blood pressure and the risk for spontaneous hypertension.

M. Pravenec, P. C. Churchill, M. C. Churchill, O. Viklicky, L. Kazdova, T. J. Aitman, E. Petretto, N. Hubner, C.A.Wallace, H.Zimdahl, V.Zidek, V.Landa, J.Dunbar, A.Bidani, K.Griffin, N.Qi, M.Maxova, V.Kren, P.Mlejnek, J.Wang, T.W.Kurtz: Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension, Nature Genetics 40:952-954, 2008, IF=25.556

Author: pravenec@biomed.cas.cz

22.3.2010 - 25th International Symposium on MicroScale Bioseparations Prague, March 21-25, 2010
Welcome to the 25th International Symposium on MicroScale Bioseparations Prague, March 21-25, 2010

11.6.2009 - Laser microdissection system Leica LMD600
Laser microdissection system Leica LMD600 was installed in the Institute of Physiology.

03.6.2009 - FLIM seminar
June 3, 2009: Seminar on Fluorescence Lifetime Imaging Techniques at the Institute of Physiology

28.5.2009 -  INVITATION
8th EUROPEAN FORUM FOR SCIENCE AND TECHNOLOGY

18.2.2009 - The Honorary Medal of J. E. Purkynje for Dr. Jaroslav Kunes
The Honorary Medal of J. E. Purkynje for Dr. Jaroslav Kunes

03.12.2008 - Journal article in prestige journal Nature Genetics
The article in prestige journal Nature Genetics on molecular-genetic basis of severe inherited mitochondrial disease – neonatal encephalo-cardiomyopathy.

03.12.2008 - Review articles in prestige journal Nature Genetics
Identification of distribution and functional impact of DNA copy number variation in the rat

27.8.2008 - IMPORTANT INFORMATION FOR FOREIGNERS FROM THIRD COUNTRIES
Nowadays, the research workers can apply for the long-term residence permission (not anymore for the visa granted for a stay longer than 90 days) for the purpose of scientific research.

15.7.2008 - EBBS Award for Dr. Stuchlik
European Brain and Behaviour Society 40th Anniversary Award