Research topics
Molecular mechanisms of Wnt signaling in mammalian cells. Signaling pathways influencing behavior of normal and diseased intestinal epithelial cells.
Current Grant Support
Ministry of Education, Youth and Sports of the Czech Republic (Center of Molecular and Cellular Immunology, 1M0506);
Ministry of Education, Youth and Sports of the Czech Republic (NPV II Program, qCHIP/chip06, 2B06077)
Grant Agency of the Czech Republic (grants No's: GA204/06/1658, GA204/07/1567)
Most important recent papers
(2004-present; names of the lab members underlined)Wilson, E.M., Tureckova J., Rotwein, P.: Permissive roles of phosphatidyl inositol 3-kinase and Akt in skeletal myocyte maturation. Mol. Biol. Cell. 15: 497-505, 2004.
Tureckova, J.,Vojtechova, M., Kucerova, D., Velek, J., Tuhackova, Z.: Sodium butyrate-mediated differentiation of colorectal cancer cells: regulation of PKCbetaII by PI 3-kinase. Int. J. Mol. Med. 15: 329-35, 2005.
Tureckova, J., Kucerova, D.,Vojtechova, M., Sloncova, E., Tuhackova, Z.: Expression of beta-catenin is regulated by PI-3 kinase and sodium butyrate in colorectal cancer cells. Int. J. Mol. Med. 17: 69-75, 2006.
Stokrova, J., Sloncova, E., Sovova, V., Zila, V., Tureckova, J., Vojtechova, M., Korb, J., Tuhackova, Z.: Characterization of four clones derived from human adenocarcinoma cell line, HT29, and analysis of their response to sodium butyrate. Int. J. Oncol. 28: 559-65, 2006.
Valenta, T., Lukas, J., Doubravska, L., Fafilek, B., Korinek, V.: HIC1 attenuates Wnt signaling by recruitmentof TCF-4 and beta-catenin to the nuclear bodies. The EMBO Journal 25: 2326-2337, 2006.
Asahina, M., Valenta, T., Silhankova, M., Korinek, V., Jindra, M.: Crosstalk between a Nuclear Receptor and beta-Catenin Signaling Decides Cell Fates in the C. elegans Somatic Gonad. Developmental Cell 11: 203-211, 2006.
Doubravská L, Simova S, Cermak L, Valenta T, Korínek V, Andera L.: Wnt-expressing rat embryonic fibroblasts suppress Apo2L/TRAIL-induced apoptosis of human leukemia cells. Apoptosis 13: 573-87, 2008.