O ústavu Výzkum Studium Knihovna Časopis Aktuality Nabídka práce Hledání
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Scientists
Mgr Jan Jakubik, PhD
Ing Pavel Michal, PhD
Mgr Vladimir Rudajev
 
Technical Assistants
Romana Ondrejova
Dana Ungerova
Jana Vobornikova

PhD students
Mgr Eva Machova
 
Pregradual studets
Helena Pizova
Alena Randakova
Helena Smyckova
Eva Santruckova
Pavel Zimcik
 

Department: Neurochemistry
Head: MUDr Vladimir Dolezal, DrSc
Contact phone/fax number: +420 296442287 / +420 296442488
e-mail: dolezalbiomed.cas.cz
 
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Main Topics:
  		 
  1. Biochemical physiology and pharmacology of cholinergic neurons. Development and differentiation of cholinergic neurons. Synthesis, storage, and release of acetylcholine. Presynaptic regulation of acetylcholine release.
  2. Cholinergic mechanisms in pathogenesis of Alzheimer´s disease. Influence of beta-amyloid on acetylcholine metabolism and muscarinic transmission.
  3. Molecular pharmacology of muscarinic receptors. Allosteric modulation of receptor activation. Interaction of muscarinic receptors with G-proteins. Modeling of muscarinic receptor signal transduction.


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