Research topics
Transcriptional factors, Pax genes, eye development and evolution, brain development
More information can be found on the lab webpage.
Current grant support
Ministry of Education, Youth and Sports of the Czech Republic (Center of Applied Genomics, grant No.: 1M0520)
Grant Agency of the Czech Republic (grant No.: GA204/08/1618)
Grant Agency of the Academy of Sciences of the Czech Republic (grant No.: IAA500520604)
Grant Agency of the Charles University in Prague (grant No.: 91808)
Most important recent papers
(2005-present; names of the lab members underlined)Machon, O., Backman M., Krauss S., Kozmik Z.: The cellular fate of cortical progenitors is not maintained in neurosphere cultures. Mol. Cell. Neurosci. 30: 388-97, 2005. (PubMed)
Backman, M., Machon, O., Mygland, L., van den Bout, C.J., Zhong, W., Taketo, M.M., Krauss, S.: Effects of canonical Wnt signalling on dorso-ventral specification of the mouse telencephalon. Dev. Biol. 279: 155-68, 2005. (PubMed)
Kozmik, Z., Holland, N.D., Kreslova, J., Oliveri, D., Schubert, M., Jonasova, K., Holland, L.Z., Pestarino, M., Benes, V., Candiani, S.: Pax-Six-Eya-Dach network during amphioxus development: Conservation in vitro but context-specificity in vivo. Dev Biol. 306: 143-59, 2007. (PubMed)
Fujimura, N., Vacik, T., Machon, O., Vlcek, C., Scalabrin, S., Speth, M., Diep, D., Krauss, S., Kozmik, Z.: Wnt-mediated down-regulation of Sp1 target genes by a transcriptional repressor Sp5. J. Biol. Chem. 282: 1225-37, 2007. (PubMed)
Kreslova J, Machon O, Ruzickova J, Lachova J, Wawrousek EF, Kemler R, Krauss S, Piatigorsky J, Kozmik Z. Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function. Genesis. 2007 Apr 4;45(4):157-168. (PubMed)
Machon O, Backman M, Machonova O, Kozmik Z, Vacik T, Andersen L, Krauss S. A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus. Dev Biol. 2007 Nov 1;311(1):223-37. (PubMed)
Kozmik Z, Swamynathan SK, Ruzickova J, Jonasova K, Paces V, Vlcek C, Piatigorsky J. Cubozoan crystallins: evidence for convergent evolution of pax regulatory sequences. Evol Dev. 2008 Jan-Feb;10(1):52-61. (PubMed)
Holland LZ, Albalat R, Azumi K, Benito-Gutierrez E, Blow MJ, Bronner-Fraser M, Brunet F, Butts T, Candiani S, Dishaw LJ, Ferrier DE, Garcia-Fernandez J, Gibson-Brown JJ, Gissi C, Godzik A, Hallböök F, Hirose D, Hosomichi K, Ikuta T, Inoko H, Kasahara M, Kasamatsu J, Kawashima T, Kimura A, Kobayashi M, Kozmik Z, Kubokawa K, Laudet V, Litman GW, McHardy AC, Meulemans D, Nonaka M, Olinski RP, Pancer Z, Pennacchio LA, Pestarino M, Rast JP, Rigoutsos I, Robinson-Rechavi M, Roch G, Saiga H, Sasakura Y, Satake M, Satou Y, Schubert M, Sherwood N, Shiina T, Takatori N, Tello J, Vopalensky P, Wada S, Xu A, Ye Y, Yoshida K, Yoshizaki F, Yu JK, Zhang Q, Zmasek CM, Putnam NH, Rokhsar DS, Satoh N, Holland PW The amphioxus genome illuminates vertebrate origins and cephalochordate biology Genome Res. 2008 Jul;18(7):1100-11. (PubMed)
Kozmik Z, Ruzickova J, Jonasova K, Matsumoto Y, Vopalensky P, Kozmikova I, Strnad H, Kawamura S, Piatigorsky J, Paces V, Vlcek C. Assembly of the cnidarian camera-type eye from vertebrate-like components. Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):8989-93. (PubMed)
Reviews
Kozmik, Z.: Pax genes in eye development and evolution. Review. Curr. Opin. Genet. Dev. 15: 430-8, 2005. (PubMed)
Jonasova K, Kozmik Z. Eye evolution: Lens and cornea as an upgrade of animal visual system. Semin Cell Dev Biol. 2007 Oct 13. (PubMed)
Kozmik Z The role of Pax genes in eye evolution. Brain Res Bull. 2008 Mar 18;75(2-4):335-9. (PubMed)