Research topics
Immunoregulation, transplantation immunity, stem cells research, regulatory T cells, cytokines and other immunoregulatory molecules, gene expression.
Current grant support
Grant Agency of the Czech Republic Nos. 309/06/0121 and 310/08/H077, EU Programme No. GA 222509, Grant Agency of the Ministry of Education No. 1M0506, Academy of Science of the Czech Republic project No. KAN200520804
Most important recent papers
(2004-present; names of the lab members underlined)Krulová, M., Zajícová, A., Frič, J., Holáň, V.: Alloantigen-induced, T cell-dependent production of nitric oxide by macrophages infiltrating skin allografts. Transplant Int. 15: 108-116, 2002. (PubMed)
Plšková, J., Duncal, L., Holáň, V., Filipec, M., Kraal, G., Forrester, J. V.: The immune response to corneal allograft requires a site-specific draining lymph node. Transplantation 73: 210-215, 2002. (PubMed)
Holáň, V., Krulová, M., Zajícová, A., Pindjáková, J.: Nitric oxide as a regulatory and effector molecule in the immune system. Mol. Immunol. 38: 989-995, 2002. (PubMed)
Holáň, V., Vítová, A., Pindjáková, J., Krulová, M., Zajícová, A., Filipec, M.: Corneal stromal cells selectively inhibit production of anti-inflammatory cytokines by activated T cells. Clin. Exp. Immunol. 136: 200-206, 2004. (PubMed)
Vítová, A., Filipec, M., Zajícová, A., Krulová, M., Holáň, V.: Prevention of corneal allograft rejection in a mouse model of high-risk recipients. Br. J. Ophthalmol. 88: 1338-1342, 2004. (PubMed)
Holáň, V., Pindjáková, J., Zajícová, A., Krulová, M., Železná, B., Matoušek, P., Svoboda, P.: The activity of inducible nitric oxide synthase in rejected skin xenografts is selectively inhibited by a factor produced by grafted cells. Xenotransplantation 12: 227-234, 2005. (PubMed)
Pindjáková, J., Vítová, A., Krulová, M., Zajícová, A., Filipec, M., Holáň, V.: Corneal rat-to-mouse xenotransplantation and the effects of anti-CD4 or anti-CD8 treatment on cytokine and nitric oxide production. Transplant Int. 18: 854-862, 2005. (PubMed)
Holáň, V., Pindjáková, J., Krulová, M., Neuwirth, A., Zajícová, A., Frič, J.: Production of nitric oxide during graft rejection is regulated by the Th1/Th2 balance, the arginase activity and L-arginine metabolism. Transplantation 81, 1708-1715, 2006.)
Kubera M., Roman A., Basta-Kaim A., Budziszewska B., Zajícová A., Holáň V., Rogoz Z., Skuza G., Leskiewicz M., Regulska M., Jogla G., Nowak G., Lason W.: Effect of acute and repeated treatment with mirtazapine on the immunity of noradrenaline transporter knockout C57BL/6J mice. Pharmacol. Biochem. Behaviour 85, 813-819, 2006.
Tavandzi U., Procházka R., Usvald D, Hlučilová J., Vitásková M., Motlík J., Vítová A., Filipec M., Forrester J. V., Holáň V.: A new model of corneal transplantation in the miniature pig. Efficacy of immunosuppressive treatment. Transplantation 83, 000-000, 2007.
Piálek J., Vyskočilová M., Bímová B., Havelková D., Piálková J., Dufková P., Bencová V., Dureje L., Albrecht T., Hauffe H. C., Macholán M., Munclinger P., Storchová R., Zajícová A., Holáň V., Gregorová S., Forejt J.: Development of unique house mouse resources suitable for evolutionary studies of speciation. J. Heredit. 99, 34-44, 2008.
Frič J., Marek M., Hrušková V., Holáň V., Forstová J.: Cellular and humoral immune responses to chimeric EGFP-pseudocapsids derived from the mouse polyomavirus after their intranasal administration. Vaccine 26, 3242-3251, 2008.
Krulová M., Pokorná K., Lenčová A., Zajícová A., Frič J., Filipec M., Forrester J.V., Holáň V.: A rapid separation of two distinct populations of corneal epithelial cells with limbal stem cell characteristics in the mouse. Invest. Ophthalmol. Vis. Sci. 49, 3903-3908, 2008.
Reviews
Holáň, V.: Corneal stromal cells selectively inhibit the production of certain anti-inflammatory cytokines. Expert Rev. Clin. Immunol. 2: 101-108, 2006.
Teaching, lectures, public presentations
Immunology courses, Faculty of Science, Charles University, Prague, presentation for Czech students.