Review articles in prestige journal Nature Genetics

Identification of renal Cd36 as a genetic determinant of blood pressure and risk for hypertension

To search for quantitative trait loci (QTL) involved in the renal pathogenesis of essential hypertension, we integrated expression QTL analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy identified inherited variation in the renal expression of Cd36 encoding fatty acid translocase as a possible determinant of inherited variation in the risk for hypertension. In renal cross transplantation studies in SHR progenitor, transgenic, and congenic strains, selective genetic deficiency of wild type Cd36 in the kidney increased blood pressure, thereby establishing Cd36 in a novel renal gene pathway influencing blood pressure and the risk for spontaneous hypertension.
M. Pravenec, P. C. Churchill, M. C. Churchill, O. Viklicky, L. Kazdova, T. J. Aitman, E. Petretto, N. Hubner, C.A.Wallace, H.Zimdahl, V.Zidek, V.Landa, J.Dunbar, A.Bidani, K.Griffin, N.Qi, M.Maxova, V.Kren, P.Mlejnek, J.Wang, T.W.Kurtz: Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension, Nature Genetics 40:952-954, 2008, IF=25.556

Author: pravenecbiomed.cas.cz
 

Review articles in prestige journal Nature Genetics
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Review articles in prestige journal Nature Genetics
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