Article: Diabetologia

n-3 fatty acids and rosiglitazone exerts additive effects on muscle glycogen synthesis in mice fed a high-fat diet

Combined effects of n-3 polyunsaturated fatty acids (n-3 PUFA) and rosiglitazone were studied on a murine model of obesity and insulin resistance. Male C57BL/6 mice were fed for 5-20 weeks (i) high-fat (HF) diet (35 g fat/100 g diet); (ii) HF diet with n-3 PUFA concentrate replacing 15% dietary lipids; (iii) HF diet with 10 mg rosiglitazone /kg diet; (iv) combination of both n-3 PUFA and rosiglitazone. The combination exerted additive effects in prevention of obesity and associated low-grade adipose tissue inflammation, dyslipidaemia, and insulin resistance, while inducing adiponectin, suppressing hepatic lipogenesis and decreasing muscle ceramide concentration. The improvement in glucose tolerance reflected a synergistic stimulatory effect of the combination treatment on muscle sensitivity to insulin. The combination treatment may reduce dose requirements and hence the incidence of adverse side-effects of rosiglitazone therapy.
Kuda O, Jelenik T, Jilkova Z, Flachs P, Rossmeisl M, Hensler M, Kazdova L, Ogston N, Baranowski M, Gorski J, Janovska P, Kus V, Polak J, Mohamed-Ali V, Burcelin R, Cinti S, Bryhn M, Kopecky J.: n-3 fatty acids and rosiglitazone improve insulin sensitivity through additive stimulatory effects on muscle glycogen synthesis in mice fed a high-fat diet. Diabetologia. 2009 May;52(5):941-51. IF=5.85

Author: kuda@biomed.cas.cz
 

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