Journal article: FASEB

In vivo content of mitochondrial ATP synthase is controlled by expression of the gene encoding hydrophobic subunit c.

ATP synthase, the key enzyme of ATP production in mammalian cell is composed of 16 different types of subunits. Joint project with the University of Stockholm showed that tissue specific differences in the enzyme content correlate with a selectively regulated expression of the P1 isogene of subunit c, a component of proton-translocating channel of the membrane sector of ATP synthase, the availability of which could control biogenesis of the enzyme.
With the help of transgenic hyperexpression of P1 isogene, this hypothesis was confirmed by induction of ATP synthase in brown adipose tissue, in which the content of this enzyme is normally very low.
Kramářova TV, Shabalina IG, Anderson U, Westerberg R, Carlberg I, Houstek J, Nedergaard J and Canon B: Mitochondrial ATP-synthase levels in brown adipose tissue are governed by the c-Fo subunit P1 isoform. FASEB J. 2008, 22(1):55-63. IF= 8.8

Author: houstekbiomed.cas.cz

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