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Institute of Physiology ASCR, v.v.i.
Videnska 1083
CZ-14220 Prague 4
Czech Republic

Phone:     +420 24106 1111
                  +420 24447 2270
Fax:          +420 24106 2488

E-mail: fgubiomed.cas.cz
 

 

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03.12.2008 - Review articles in prestige journal Nature Genetics

Identification of renal Cd36 as a genetic determinant of blood pressure and risk for hypertension

To search for quantitative trait loci (QTL) involved in the renal pathogenesis of essential hypertension, we integrated expression QTL analysis of the kidney with genome-wide correlation analysis of renal expression profiles and blood pressure in recombinant inbred strains derived from the spontaneously hypertensive rat (SHR). This strategy identified inherited variation in the renal expression of Cd36 encoding fatty acid translocase as a possible determinant of inherited variation in the risk for hypertension. In renal cross transplantation studies in SHR progenitor, transgenic, and congenic strains, selective genetic deficiency of wild type Cd36 in the kidney increased blood pressure, thereby establishing Cd36 in a novel renal gene pathway influencing blood pressure and the risk for spontaneous hypertension.

M. Pravenec, P. C. Churchill, M. C. Churchill, O. Viklicky, L. Kazdova, T. J. Aitman, E. Petretto, N. Hubner, C.A.Wallace, H.Zimdahl, V.Zidek, V.Landa, J.Dunbar, A.Bidani, K.Griffin, N.Qi, M.Maxova, V.Kren, P.Mlejnek, J.Wang, T.W.Kurtz: Identification of renal Cd36 as a determinant of blood pressure and risk for hypertension, Nature Genetics 40:952-954, 2008, IF=25.556

Author: pravenec@biomed.cas.cz




22.3.2010 - 25th International Symposium on MicroScale Bioseparations Prague, March 21-25, 2010
Welcome to the 25th International Symposium on MicroScale Bioseparations Prague, March 21-25, 2010

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02.11.2009 - Seminar
POTASSIUM AND SODIUM HOMEOSTASIS IN YEASTS

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11.6.2009 - Laser microdissection system Leica LMD600
Laser microdissection system Leica LMD600 was installed in the Institute of Physiology.

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03.6.2009 - FLIM seminar
June 3, 2009: Seminar on Fluorescence Lifetime Imaging Techniques at the Institute of Physiology

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28.5.2009 -  INVITATION
8th EUROPEAN FORUM FOR SCIENCE AND TECHNOLOGY

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21.5.2009 - Special Award for Dr. Pavel Flachs
Dr. P. Flachs was awarded with Otto Wichterle Premium

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18.2.2009 - The Honorary Medal of J. E. Purkynje for Dr. Jaroslav Kunes
The Honorary Medal of J. E. Purkynje for Dr. Jaroslav Kunes

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03.12.2008 - Journal article in prestige journal Nature Genetics
The article in prestige journal Nature Genetics on molecular-genetic basis of severe inherited mitochondrial disease – neonatal encephalo-cardiomyopathy.

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03.12.2008 - Review articles in prestige journal Nature Genetics
Identification of distribution and functional impact of DNA copy number variation in the rat

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