Department of Pharmacology

Canová, N., Kmoníčková, E., Lincová, D., Vítek, L., Farghali, H.: (2004) Evaluation of a flat membrane hepatocyte bioreactor for pharmacotoxicological applications: evidence that inhibition of spontaneously produced nitric oxide improves cell functionality. Altern. Lab. Anim. 32: 25–35.

Kmoníčková, E., Zídek, Z.: (2004) Quantitative Aspects of lipopolysaccharide and Cytokine Requirements to Generate Nitric Oxide in Macrophages from LPS-Hyporesponsive (LPSd) C3H/HEJ Mice. Folia Microbiol. 49(6): 737–744.

Zídek, Z., Kmoníčková, E., Holý, A.: (2004) Involvement of adenosine A(1) receptors in upregulation of nitric oxide by acyclic nucleotide analogues. Eur. J. Pharmacol. 501 (1–3): 79–86.

Česnek, M., Holý, A., Masojídková, M., Zídek, Z.: (2005) Synthesis of 9-alkyl and 9-heteroalkyl substituted 2-amino-6-guanidinopurines and their influence on the NO-production in macrophages. Bioorg. Med. Chem. 13: 2917–2926.

Doláková, P., Holý, A., Zídek, Z., Masojídková, M., Kmoníčková, E.: (2005) Synthesis and immunobiological activity of base substituted 2-amino-3-(purin-9-yl)propanoic acid derivatives. Bioorg. Med. Chem. 13: 2349–2354.

Drahota, Z., Křiváková, P., Červinková, Z., Kmoníčková, E., Lotková, H., Kučera, O. Houštěk, J.: (2005) Tert-butyl hydroperoxide selectively inhibits mitochondrial respiratory-chain enzymes in isolated rat hepatocytes. Physiol. Res. 54: 67–72.

Čejková, J., Ardan, T., Čejka, Č., Kovačeva, J., Zídek, Z.: (2005) Irradiation of the rabbit cornea with UVB rays stimulates the expression of nitric oxide synthases-generated nitric oxide and the formation of cytotoxic nitrogen-related oxidants. Histol. Histopathol. 20(2): 467–473.

Botros, S., Mahmoud, M., Hammam, O., Salah, F., Zídek, Z., Mašek, K.: (2006) Effect of adamantylamide dipeptide as adjuvant therapy to praziquantel in mice infected with different S. mansoni isolates. APMIS 114(7–8): 480–491. PDF file (717 kB)

Kmoníčková, E., Potměšil, P., Holý, A., Zídek, Z.: (2006) Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of Zdenině and 2,6-diaminopurine. Eur. J. Pharmacol. 530(1–2): 179–187. PDF file (776 kB)

Kutinová-Canová, N., Lincová, D., Kmoníčková, E., Kameníková, L., Farghali H.: (2006) Nitric oxide production from rat adipocytes is modulated by beta3-adrenergic receptor agonists and is involved in a vycliv AMP-dependent lipolysis in adipocytes. Nitric Oxide 14: 200–211. PDF file (360 kB)

Nekvindová, J., Veinlichová, A., Mašek, V., Anzenbacherová, E., Anzenbacher, P., Zídek, Z., Holý, A.: (2006) Inhibition of human liver microsomal cytochrome P450 activities by adefovir and tenofovir. Xenobiotica 36(12): 1165–1177. PDF file (485 kB)

Potměšil, P., Krečmerová, M., Kmoníčková, E., Holý, A., Zídek, Z.: (2006) Nucleotide analogues with immunobiological properties: 9-[2-Hydroxy-3-(phosphonomethoxy)propyl]-adenine (HPMPA), -2,6-diaminopurine (HPMPDAP), and their N(6)-substituted derivatives. Eur. J. Pharmacol. 540(1–3): 191–199. PDF file (576 kB)

Zídek, Z., Anzenbacher, P., Anzenbacherová, E., Buchar, E., Kmoníčková, E., Potměšil, P., Holý, A.: (2006) In vivo effects of antiviral acyclic nucleoside phosphonate 9-[2-(phosphonomethoxy)ethyl]adenine (adefovir) on cytochrome P450 system of rat liver microsomes. J. Biomed. Sci. 13(3): 295–301. PDF file (272 kB)

Hodis, J., Kutinová-Cánová, N., Potměšil, J., Kameníková, L., Kmoníčková, E., Zídek, Z., Hassan, F.: (2007) The role of adrenergic agonists on glycogenolysis in rat hepatocyte culture and possible involving of NO. Physiol. Res. 56(4): 419–425. PDF file (251 kB)

Kmoníčková, E., Melkusová, P., Farghali, H., Holý, A., Zídek. Z.: (2007) Nitric oxide production in mouse and rat macrophages: A rapid and efficient assay for screening of drugs immunostimulatory effects in human cells. Nitric Oxide 17: 160–169. PDF file (277 kB)

Kutinová-Cánová N., Kmoníčková, E., Martínek, J., Zídek, Z., Farghali, H.: (2007) Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+ -ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture. Cell Biol. Toxicol. 23(5): 337–354. PDF file (606 kB)

Potměšil P., Holý, A., Kmoníčková, E., Křížková, J., Zídek, Z.: (2007) Acyclic nucleoside phosphonate antivirals activate gene expression of monocyte chemotactic protein 1 and 3. J. Biomed. Sci. 14(1): 59–66. PDF file (284 kB)

Zídek, Z., Kmoníčková, E., Holý, A.: (2007) Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates. Eur. J. Pharmacol. 574: 77–84. PDF file (551 kB)