The group of Chemistry of Functional Molecules is focused on the preparation and use of helicenes and their congeners. Recently, an original approach to helicene frameworks has been developed that is based on [2+2+2] cycloisomerization of aromatic triynes under transition metal catalysis. This approach represents a new paradigm for the non-photochemical preparation of helicenes and their substituted derivatives in an easy, convergent, and modular way. The methodology has matured to serve as a reliable and general synthetic tool providing tailor-made helically chiral targets.

An example of the helicene synthesis:

Selected compounds prepared recently:

Diastereoselective synthesis of helicene-like compounds:

Grant Support

Grant Agency of the Czech Republic
Study of Electron Flow in Functional π-Electron Systems: En Route to Molecular Electronic Devices, N° 203/06/1792
[ I. Starý (2006-2008) ]

Ministry of Education, Youth and Sports
Center for Biomolecules and Complex Molecular Systems, Reg. N° LC05A57
[ I. Starý (2005-2009) ]

Pico-Inside, FP6-2004-IST FET "Emerging Nanoelectronics", Reg. N° 15847 Computing Inside a Single Molecule Using Atomic Scale Technologies [ I. G. Stará (2005-2009) ]

Ministry of Education, Youth and Sports and NSF USA, Reg. N° ME857
Collaboration in the Field of Energy and Nanoscience: USA and Europe
[ I. Starý (2006-2008) ]

Grant Agency of the Czech Republic
Synthesis of Nonracemic Helical Aromatics Employing Transition Metal Catalysis, N° 203/07/1664
[ I.G. Stará (2007-2009) ]

Grant Agency of ASCR
Fullerene Containers. Design, Synthesis, Properties and Possible Application, N° A 400550704
[ P. Holý (2007-2011) ]

Collaboration

Dr. Dirk Blunk (Institut für Organische Chemie, Universität zu Köln, Germany)
Dr. Ivana Císařová (Department of Inorganic Chemistry, Faculty of Science, Charles University, Prague, Czech Republic)
Dr. Josef Cvačka (IOCB AS CR Prague, Czech Republic)
Prof. Gérald Dujardin (Laboratoire de PhotoPhysique Moléculaire, Université Paris Sud, Orsay, France)
Dr. Jean-Olivier Durand (Chimie Moléculaire et Organisation du Solide, Institut Charles Gerhardt, Université Montpellier 2, France)
Prof. Peter Eilbracht (Fachbereich Chemie, Universität Dortmund, Germany)
Dr. Marko Hapke (Leibniz-Institut für Katalyse, Universität Rostock, Germany)
Dr. Barbara Heller (Leibniz-Institut für Katalyse, Universität Rostock, Germany)
Prof. Sylvain Jugé (Faculté des Sciences Gabriel, Université de Bourgogne, Dijon, France)
Prof. Guy Lloyd-Jones (The Bristol Centre for Organometallic Catalysis, School of Chemistry, UK)
Dr. Václav Kašička (IOCB AS CR Prague, Czech Republic)
Prof. Pavel Kočovský (Department of Chemistry, University of Glasgow, UK)
Prof. Ernst Meyer (Department of Physics und Astronomy, Basel University, Switzerland)
Prof. Josef Michl (Department of Chemistry and Biochemistry, University of Colorado, Boulder, USA, and IOCB Prague)
Prof. John Miller (Chemistry Department, Brookhaven National Laboratory, Upton, USA)
Dr. Dana Nachtigallová (IOCB AS CR Prague, Czech Republic)
Prof. Lubomír Pospíšil (J. Heyrovský Institute of Physical Chemistry, Prague, Czech Republic)
Dr. Lubomír Rulíšek (IOCB AS CR Prague, Czech Republic)
Dr. Luděk Rydvan (Zentiva Prague, Czech Republic)
Dr. Detlef Schröder (IOCB AS CR Prague, Czech Republic)
Prof. Richard Stephenson (School of Chemical Sciences and Pharmacy, University of East Anglia Norwich, UK)
Prof. Marek Szymonski (Department of Physics of Nanostructures and Nanotechnology, Jagiellonian University, Krakow, Poland)
Dr. David Šaman (IOCB AS CR Prague, Czech Republic)
Prof. Stephen Urquart (University of Saskatchewan, Saskatoon, Canada)
Prof. Graham Bodwell (Memorial University, St. John's, Canada)
Prof. Pat Guiry (University College Dublin, Dublin, Ireland)

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