11.1.2010 - Journal article: International Journal of Biochemistry and Cell Biology

Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I.

To elucidate pro- and anti-oxidant action of MitoQ10, we studied its effects on HEP-G2 cell respiration, mitochondrial network morphology, and rates of superoxide release (above that neutralized by superoxide dismutase) to the mitochondrial matrix (Jm). Results suggest that MitoQ10 accepts electron prior to the rotenone-bound Q-site, and the Complex II reverse mode oxidizes MitoQ10H2 to regenerate MitoQ10. Consequently, MitoQ10 has a pro-oxidant role in intact cells, whereas it serves as an antioxidant when Complex I-derived superoxide generation is already elevated due to electron flow retardation.

Plecitá-Hlavatá L, Ježek J, Ježek P.: Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I. International Journal of Biochemistry and Cell Biology 2009; 41:1697-1707. IF=4.178

 

Author: plecita@biomed.cas.cz

01.1.2013 - BIOCEV
BIOTECHNOLOGY AND BIOMEDICINE CENTER OF THE ACADEMY OF SCIENCES AND CHARLES UNIVERSITY IN VESTEC

10.6.2010 - Award of the President of the Czech Granting Agency
RNDr. Ales Stuchlik PhD has been awarded by the Award of the President of the Czech Granting Agency

02.6.2010 - Otto Wichterle Premium
Martin Sládek, Ph.D. was awarded the Otto Wichterle Premium

28.4.2010 - 6th International meeting of biomedical doctoral schools
Institute of Physilology, AS CR, v.v.i. and the 2nd Faculty of Medicine, Charles University organize the 6th meeting

22.3.2010 - 25th International Symposium on MicroScale Bioseparations Prague, March 21-25, 2010
Welcome to the 25th International Symposium on MicroScale Bioseparations Prague, March 21-25, 2010

13.1.2010 - Journal article: Endocrinology
Chronic Intermittent Hypoxia Induces 11Beta-Hydroxysteroid Dehydrogenase in Rat Heart.

12.1.2010 - Journal article: Epilepsia
Antagonists of group I metabotropic glutamate receptors and cortical afterdischarges in immature rats.

10.1.2010 - Journal article: Chronobiology International
Temporal Gradient in the Clock Gene and Cell-Cycle Checkpoint Kinase Wee1 Expression along the Gut.

09.1.2010 - Journal article: Journal of Neurophysiology
The Role of The TRPV1 Endogenous Agonist N-Oleoyldopamine in Modulation of Nociceptive Signaling at the Spinal Cord Level.

08.1.2010 - Journal article: Proceedings of the National Academy of Sciences of the USA
Spatial decisions and cognitive strategies of monkeys and humans based on abstract spatial stimuli in rotation test.