APPLICATION OF MICROWAVES AT CYCLISATION

       REACTION ON SOLID SUPPORTS

Staff:

Vladimír Církva, Stanislav Relich, Lenka Slavětínská, Leona Vlková

External co-workers:

Oldřich Paleta, Jaroslav Kvíčala, Jiří Paleček (Institute of Chemical Technology (ICT) Prague, Department of organic chemistry)
 

 

 

Financing, funding:

Czech Science Foundation (grant 203/02/0306) New cyclisation reaction affording dinitrogen heterocycles

 

 

Why newly microwaves and solid supports?

 

   Reactions under "dry" conditions (i.e. in the absence of a solvent on a solid support) at microwave irradiation offer several advantages:

a) The absence of solvent reduces the risk of explosions, moreover, aprotic solvents with high boiling points are expensive and difficult to remove from the reaction mixtures.

b) During microwave irradiation of reactions under dry conditions, the reactants adsorbed on the surface of alumina, silica gel, clay, and others absorb the microwaves whereas the support does not, nor does it restrict the transmission of microwaves.

c) Consequently, such supported reagents efficiently induce reactions under safe and simple conditions, and such methods are now ecologically desirable.

 

 

Solved problems:

 

Effect of microwaves on regio- and diastereo-selectivity at cyclisation

of 2-aminobenzylamine, ketone and methyl trifluoropyruvate

more ...

 

 

 

 

 

Publications:

[1]

 

 

 

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