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Department of Cellular Neurophysiology

Head: Miroslava Anděrová, PhD
E-mail: anderovaatbiomed [dot] cas [dot] cz
Phone: +420 241 062 050

 

Laboratory of Molecular Neurophysiology

Assoc. Prof. Alexandr Chvátal, PhD, DSc, MBA | Head of Laboratory
E-mail: chvatalatbiomed [dot] cas [dot] cz
Phone: +420 241 062 670
 
Alexandr Chvátal, PhD, DSc, MBA| Research Scientist
Alexey Verkhratsky, MD, PhD, DSc| Research Scientist
José Julio Rodríguez Arellano, PhD| Research Scientist
Magdaléna Kuliewicz, MSc| PhD Student
 

 

Laboratory of the Physiology of Calcium Signalling

Govindan Dayanithi, PhD | Head of Laboratory
E-mail: gdayaatuniv-montp2 [dot] fr
Phone: +420 241 062 725
 
Govindan Dayanithi, PhD| Research Scientist CNRS
Oksana Forostyak, MD| PhD Student
 
 

Laboratory of Neurobiology

Miroslava Anděrová, PhD | Head of Laboratory
E-mail: anderovaatbiomed [dot] cas [dot] cz
Phone: +420 241 062 050
 
Miroslava Anděrová, PhD| Research Scientist
Helena Neprašová, MD| PhD Student
Iva Prajerová, MSc| PhD Student
Jana Benešová, MSc| PhD Student
Olena Butenko, MSc| PhD Student
Pavel Honsa, MSc| PhD Student
Dávid Džamba, MSc| PhD Student
Veronika Dlouhá| Undergraduate Student
Michaela Mikešová| Undergraduate Student
Lenka Harantová| Undergraduate Student
Marcela Filipová| Undergraduate Student
Helena Pavlíková| Technician
Markéta Valová | Secretary

 

Research topics

Characterization of intercellular signaling pathways within neuronal-glial circuits and intracellulal signaling mechanisms in neurons and glia under physiological and pathological conditions:
  • The role of glutamergic and purinergic pathways in neuronal-glial signalling in the cortex, hippocampus and spinal cord with a specific emphasis on the glial NMDA and P2X receptors;
  • In vivo imaging of neuronal-glial circuits under physiological and pathophysiological conditions;
  • Calcium signalling cascades in Alzheimer’s disease; the morphology and physiology of glia during normal brain ageing.
 
Molecular Physiology of Calcium Signalling:
  • The physiology of vasopressin and oxytocin signalling in neuron-glia interactions, injury, nociception, pregnancy and lactation in the central and peripheral nervous systems;
  • The physiology of the hypothalamo-neurohypophysial system and stimulus-secretion coupling in the neurohypophysis;
  • The physiology of calcium signalling in human embryonic stem cell-derived neural precursors in the control of proliferation and differentiation.
 
Cellular, molecular and morphological changes in neurons and glial cells during pathological states:
  • The role of ion channels/transporters in astrocytic regulatory volume processes during oxygen-glucose deprivation or hypoosmotic stress;
  • The membrane properties of reactive glia and ongoing glia proliferation, cell death and glial scar formation;
  • Three-dimensional reconstruction of glial cells and their morphometric analysis;
  • Glial expression of TRP channels under physiological/pathological conditions
 
Ion channels and calcium signaling in neural stem/progenitor cells at different stages of differentiation and their functional properties after transplantation into the injured CNS: 
  • The role of  morphogenes on the differentiation potential of neonatal neural stem/ progenitor cells;
  • Differentiation of region-specific neural stem/progenitor cells after their transplantation into the ischemic brain;
  • The role of glial cells in CNS regeneration
 
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