09.1.2010 - Journal article: Journal of Neurophysiology

The Role of The TRPV1 Endogenous Agonist N-Oleoyldopamine in Modulation of Nociceptive Signaling at the Spinal Cord Level.

OLDA application in acute spinal cord slices leads to significant increase of AMPA mediated mEPSC frequency in high concentration. After PKC activation or under pathological conditions only low concentration is needed. Presynaptic spinal cord TRPV1 receptors have a significant modulatory role in nociceptive signalling and may be activated by low concentrations of endogenous agonists like OLDA under pathological conditions.

Špicarová D, Paleček J.: The Role of The TRPV1 Endogenous Agonist N-Oleoyldopamine in Modulation of Nociceptive Signaling at the Spinal Cord Level. Journal of Neurophysiology 2009; 102: 234-243.IF=3.648

 

Author: dianaspicarova@biomed.cas.cz

01.1.2013 - BIOCEV
BIOTECHNOLOGY AND BIOMEDICINE CENTER OF THE ACADEMY OF SCIENCES AND CHARLES UNIVERSITY IN VESTEC

10.6.2010 - Award of the President of the Czech Granting Agency
RNDr. Ales Stuchlik PhD has been awarded by the Award of the President of the Czech Granting Agency

08.6.2010 - Prof. Bohuslav Ostadal, MD, PhD, has been awarded by the Gold Medal of Prof. Vaclav Libensky
– in the recognition of his lifetime scientific achievements in experimental cardiology

02.6.2010 - Otto Wichterle Premium
Martin Sládek, Ph.D. was awarded the Otto Wichterle Premium

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