Research topics
Molecular mechanisms of cell fate determination and differentiation in multipotential haematopoietic and neural cells and precursors of muscle cells. Molecular mechanisms of malignant transformation of myeloid cells, melanocytes and nephrogenic blastema. Molecular mechanisms of photoinduced apoptosis in tumour cells and targeted drug delivery into tumour tissues.
Current Grant Support
Ministry of Education, Youth and Sports of the Czech Republic (Center of Cell Invasiveness in Embryonic Development and Tumour Metastases, grant No.:
LC06061; Center of Chemical Genetics, grant No.: LC06077);
Grant Agency of the Czech Republic (grants Nos. 204/06/1728, 203/06/1038);
Academy of Sciences of the Czech Republic (grants Nos. AV0Z50520514, IAA500520608, project KAN200200651)
Most important recent papers
(2005-present; names of the lab members underlined)Kaspar P, Pajer P, Sedlak D, Tamaoki T, Dvorak M. c-Myb inhibits myogenic differentiation through repression of MyoD. Exp Cell Res 309(2): 419-28, 2005. (Pubmed) (DOI)
Karafiat V, Dvorakova M, Krejci E, Kralova J, Pajer P, Snajdr P, Mandikova S, Bartunek P, Grim M, Dvorak M. Transcription factor c-Myb is involved in the regulation of the epithelial-mesenchymal transition in the avian neural crest. Cell Mol Life Sci 62(21): 2516-25, 2005. (Pubmed) (DOI)
Kral V, Lang K, Kralova J, Dvorak M, Martasek P, Chin AO, Andrievsky A, Lynch V, Sessler JL. Polyhydroxylated sapphyrins: multisite non-metallic catalysts for activated phosphodiester hydrolysis. J Am Chem Soc 128(2): 432-7, 2006. (Pubmed) (DOI)
Pajer P, Pecenka V, Kralova J, Karafiat V, Prukova D, Zemanova Z, Kodet R, Dvorak M. Identification of potential human oncogenes by mapping the common viral integration sites in avian nephroblastoma. Cancer Res 66(1): 78-86, 2006. (Pubmed) (DOI)
Nanka O, Valasek P, Dvorakova M, Grim M. Experimental hypoxia and embryonic angiogenesis. Dev Dyn 235(3): 723-33, 2006. (Pubmed) (DOI)
Karafiat V, Dvorakova M, Pajer P, Cermak V, Dvorak M. Melanocyte fate in neural crest is triggered by Myb proteins through activation of c-kit. Cell Mol Life Sci 64(22): 2975-84, 2007. (Pubmed) (DOI)
Bartunek P, Karafiat V, Bartunkova J, Pajer P, Dvorakova M, Kralova J, Zenke M, Dvorak M. Impact of chicken thrombopoietin and its receptor c-Mpl on hematopoietic cell development. Exp Hematol 36(4): 495-505, 2008. (Pubmed) (DOI)
Kralova J, Dvorak M, Koc M, Kral V. p38 MAPK plays an essential role in apoptosis induced by photoactivation of a novel ethylene glycol porphyrin derivative. Oncogene 27(21): 3010-20, 2008. (Pubmed) (DOI)
Kaspar P, Dvorak M. Involvement of phosphatidylserine externalization in the down-regulation of c-myb expression in differentiating C2C12 cells. Differentiation 76(3): 245-52, 2008. (Pubmed) (DOI)
Kralova J, Briza T, Moserova I, Dolensky B, Vasek P, Pouckova P, Kejik Z, Kaplanek R, Martasek P, Dvorak M, Kral V. Glycol porphyrin derivatives as potent photodynamic inducers of apoptosis in tumor cells. J Med Chem 51(19): 5964-73, 2008. (Pubmed) (DOI)
Zikova M, Corlett A, Bendova Z, Pajer P, Bartunek P. DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism. Mol Endocrinol 23(4): 520-8, 2009. (Pubmed) (DOI)
Pajer P, Karafiat V, Pecenka V, Prukova D, Dudlova J, Plachy J, Kasparova P, Dvorak M. Industasis, a promotion of tumor formation by nontumorigenic stray cells. Cancer Res 69(11): 4605-12, 2009. (Pubmed) (DOI)
Pekova S, Ivanek R, Dvorak M, Rueggeberg S, Leicht S, Li X, Franz T, Kozak T, Vrba J, Koza V, Karas M, Schwarz J, Cetkovsky P, Prucha M. Molecular variability of FLT3/ITD mutants and their impact on the differentiation program of 32D cells: implications for the biological properties of AML blasts. Leuk Res 33(10): 1409-16, 2009. (Pubmed) (DOI)
Kralova J, Kejik Z, Briza T, Pouckova P, Kral A, Martasek P, Kral V. Porphyrin-cyclodextrin conjugates as a nanosystem for versatile drug delivery and multimodal cancer therapy. J Med Chem 53(1): 128-38, 2010. (Pubmed) (DOI)
Other results
Application of novel bis-cyclodextrin tetrakis (pentafluorophenyl) porphyrin in the experimental tumour model for photodynamic therapy.
J. Kral (DOC) (PDF)