Research topics
Genetics and genomics of the laboratory mouse. Meiotic sex chromosome inactivation, gene expression at meiotic prophase. Hybrid sterility 1 (Prdm9) meiotic histone H3K4 tri-methyl transferase. Genetic architecture of hybrid sterility in mouse inter-sub-specific crosses (Mus m. musculus x Mus m. domesticus). Experimental introgression of musculus chromosomes into domesticus genetic background: C57BL/6J-Chr#PWD inter-sub-specific chromosome substitution strains. Positional cloning of complex trait loci and genetical genomics. Segmental trisomy of proximal 30 Mb of Chromosome 17 as a mouse model of human aneuploidy syndromes.
Current grant support
Ministry of Education, Youth and Sports of the Czech Republic (Center of Applied Genomics, grant No.: 1M68378050)
Czech Science Foundation (grant No: P305/10/1931)
Praemium Academiae (2007-2013)
AnEUploidy: Integrated project, 6th Framework Program EC (grant No.: 037627)
Most important recent papers
(2004-present; names of the lab members underlined)Divina P, Forejt J. The Mouse SAGE Site: database of public mouse SAGE libraries. Nucleic Acids Res 32(Database issue): D482-3, 2004. (Pubmed) (DOI)
Trachtulec Z, Vlcek C, Mihola O, Forejt J. Comparative analysis of the PDCD2-TBP-PSMB1 region in vertebrates. Gene 335: 151-7, 2004. (Pubmed) (DOI)
Storchova R, Gregorova S, Buckiova D, Kyselova V, Divina P, Forejt J. Genetic analysis of X-linked hybrid sterility in the house mouse. Mamm Genome 15(7): 515-24, 2004. (Pubmed)
Auwerx J, et al (including Forejt J). The European dimension for the mouse genome mutagenesis program. Nat Genet 36(9): 925-7, 2004. (Pubmed) (DOI)
Churchill GA, et al (including Forejt J). The Collaborative Cross, a community resource for the genetic analysis of complex traits. Nat Genet 36(11): 1133-7, 2004. (Pubmed) (DOI)
Vacik T, Ort M, Gregorova S, Strnad P, Blatny R, Conte N, Bradley A, Bures J, Forejt J. Segmental trisomy of chromosome 17: a mouse model of human aneuploidy syndromes. Proc Natl Acad Sci U S A 102(12): 4500-5, 2005. (Pubmed) (DOI)
Jansa P, Divina P, Forejt J. Construction and characterization of a genomic BAC library for the Mus m. musculus mouse subspecies (PWD/Ph inbred strain). BMC Genomics 6: 161, 2005. (Pubmed) (DOI)
Divina P, Vlcek C, Strnad P, Paces V, Forejt J. Global transcriptome analysis of the C57BL/6J mouse testis by SAGE: evidence for nonrandom gene order. BMC Genomics 6(1): 29, 2005. (Pubmed) (DOI)
Mihola O, Forejt J, Trachtulec Z. Conserved alternative and antisense transcripts at the programmed cell death 2 locus. BMC Genomics 8: 20, 2007. (Pubmed) (DOI)
Pialek J, Vyskocilova M, Bimova B, Havelkova D, Pialkova J, Dufkova P, Bencova V, Dureje L, Albrecht T, Hauffe HC, Macholan M, Munclinger P, Storchova R, Zajicova A, Holan V, Gregorova S, Forejt J. Development of unique house mouse resources suitable for evolutionary studies of speciation. J Hered 99(1): 34-44, 2008. (Pubmed) (DOI)
Homolka D, Ivanek R, Capkova J, Jansa P, Forejt J. Chromosomal rearrangement interferes with meiotic X chromosome inactivation. Genome Res 17(10): 1431-7, 2007. (Pubmed) (DOI)
Gregorova S, Divina P, Storchova R, Trachtulec Z, Fotopulosova V, Svenson KL, Donahue LR, Paigen B, Forejt J. Mouse consomic strains: exploiting genetic divergence between Mus m. musculus and Mus m. domesticus subspecies. Genome Res 18(3): 509-15, 2008. (Pubmed) (DOI)
Trachtulec Z, Vlcek C, Mihola O, Gregorova S, Fotopulosova V, Forejt J. Fine haplotype structure of a chromosome 17 region in the laboratory and wild mouse. Genetics 178(3): 1777-84, 2008. (Pubmed) (DOI)
Mihola O, Trachtulec Z, Vlcek C, Schimenti JC, Forejt J. A mouse speciation gene encodes a meiotic histone H3 methyltransferase. Science 323(5912): 373-5, 2009. (Pubmed) (DOI)
Teaching, lectures, public presentations
MB140P57 - Molecular Genetics of Mammalian Organisms - Faculty of Science, Charles University, Prague; semestral course in Czech.