Research topics
Transcriptional factors, Pax genes, eye development and evolution, brain development
More information can be found on the lab webpage.
Current grant support
Ministry of Education, Youth and Sports of the Czech Republic (Center of Applied Genomics, grant No.: 1M0520)
Grant Agency of the Czech Republic (grant No.: GA204/08/1618)
Grant Agency of the Czech Republic (grant No.: GA305/10/2141)
Grant Agency of the Academy of Sciences of the Czech Republic (grant No.: IAA500520604)
Grant Agency of the Academy of Sciences of the Czech Republic (grant No.: IAA500520908)
Grant Agency of the Charles University in Prague (grant No.: 91808)
Most important recent papers
(2005-present; names of the lab members underlined)Machon O, Backman M, Krauss S, Kozmik Z. The cellular fate of cortical progenitors is not maintained in neurosphere cultures. Mol Cell Neurosci 30(3): 388-97, 2005. (Pubmed) (DOI)
Backman M, Machon O, Mygland L, van den Bout CJ, Zhong W, Taketo MM, Krauss S. Effects of canonical Wnt signaling on dorso-ventral specification of the mouse telencephalon. Dev Biol 279(1): 155-68, 2005. (Pubmed) (DOI)
Kozmik Z, Holland ND, Kreslova J, Oliveri D, Schubert M, Jonasova K, Holland LZ, Pestarino M, Benes V, Candiani S. Pax-Six-Eya-Dach network during amphioxus development: conservation in vitro but context specificity in vivo. Dev Biol 306(1): 143-59, 2007. (Pubmed) (DOI)
Fujimura N, Vacik T, Machon O, Vlcek C, Scalabrin S, Speth M, Diep D, Krauss S, Kozmik Z. Wnt-mediated down-regulation of Sp1 target genes by a transcriptional repressor Sp5. J Biol Chem 282(2): 1225-37, 2007. (Pubmed) (DOI)
Kreslova J, Machon O, Ruzickova J, Lachova J, Wawrousek EF, Kemler R, Krauss S, Piatigorsky J, Kozmik Z. Abnormal lens morphogenesis and ectopic lens formation in the absence of beta-catenin function. Genesis 45(4): 157-68, 2007. (Pubmed) (DOI)
Machon O, Backman M, Machonova O, Kozmik Z, Vacik T, Andersen L, Krauss S. A dynamic gradient of Wnt signaling controls initiation of neurogenesis in the mammalian cortex and cellular specification in the hippocampus. Dev Biol 311(1): 223-37, 2007. (Pubmed) (DOI)
Kozmik Z, Swamynathan SK, Ruzickova J, Jonasova K, Paces V, Vlcek C, Piatigorsky J. Cubozoan crystallins: evidence for convergent evolution of pax regulatory sequences. Evol Dev 10(1): 52-61, 2008. (Pubmed) (DOI)
Holland LZ, Albalat R, Azumi K, Benito-Gutierrez E, Blow MJ, Bronner-Fraser M, Brunet F, Butts T, Candiani S, Dishaw LJ, Ferrier DE, Garcia-Fernandez J, Gibson-Brown JJ, Gissi C, Godzik A, Hallbook F, Hirose D, Hosomichi K, Ikuta T, Inoko H, Kasahara M, Kasamatsu J, Kawashima T, Kimura A, Kobayashi M, Kozmik Z, Kubokawa K, Laudet V, Litman GW, McHardy AC, Meulemans D, Nonaka M, Olinski RP, Pancer Z, Pennacchio LA, Pestarino M, Rast JP, Rigoutsos I, Robinson-Rechavi M, Roch G, Saiga H, Sasakura Y, Satake M, Satou Y, Schubert M, Sherwood N, Shiina T, Takatori N, Tello J, Vopalensky P, Wada S, Xu A, Ye Y, Yoshida K, Yoshizaki F, Yu JK, Zhang Q, Zmasek CM, de Jong PJ, Osoegawa K, Putnam NH, Rokhsar DS, Satoh N, Holland PW. The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Res 18(7): 1100-11, 2008. (Pubmed) (DOI)
Kozmik Z, Ruzickova J, Jonasova K, Matsumoto Y, Vopalensky P, Kozmikova I, Strnad H, Kawamura S, Piatigorsky J, Paces V, Vlcek C. Assembly of the cnidarian camera-type eye from vertebrate-like components. Proc Natl Acad Sci U S A 105(26): 8989-93, 2008. (Pubmed) (DOI)
Ruzickova J, Piatigorsky J, Kozmik Z. Eye-specific expression of an ancestral jellyfish PaxB gene interferes with Pax6 function despite its conserved Pax6/Pax2 characteristics. Int J Dev Biol 53(4): 469-82, 2009. (Pubmed) (DOI)
Fujimura N, Taketo MM, Mori M, Korinek V, Kozmik Z. Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium. Dev Biol 334(1): 31-45, 2009. (Pubmed) (DOI)
Machon O, Kreslova J, Ruzickova J, Vacik T, Klimova L, Fujimura N, Lachova J, Kozmik Z. Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm. Genesis 48(2): 86-95, 2010. (Pubmed) (DOI)
Reviews
Kozmik Z. Pax genes in eye development and evolution. Curr Opin Genet Dev 15(4): 430-8, 2005. (Pubmed) (DOI)
Jonasova K, Kozmik Z. Eye evolution: lens and cornea as an upgrade of animal visual system. Semin Cell Dev Biol 19(2): 71-81, 2008. (Pubmed) (DOI)
Kozmik Z. The role of Pax genes in eye evolution. Brain Res Bull 75(2-4): 335-9, 2008. (Pubmed) (DOI)
Vopalensky P, Kozmik Z. Eye evolution: common use and independent recruitment of genetic components. Philos Trans R Soc Lond B Biol Sci 364(1531): 2819-32, 2009. (Pubmed) (DOI)
Teaching, lectures, public presentations
MB150P83 - Model Organisms in Developmental Biology - Faculty of Science, Charles University, Prague; semestral course in Czech.