11.1.2010 - Journal article: International Journal of Biochemistry and Cell Biology

Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I.

To elucidate pro- and anti-oxidant action of MitoQ10, we studied its effects on HEP-G2 cell respiration, mitochondrial network morphology, and rates of superoxide release (above that neutralized by superoxide dismutase) to the mitochondrial matrix (Jm). Results suggest that MitoQ10 accepts electron prior to the rotenone-bound Q-site, and the Complex II reverse mode oxidizes MitoQ10H2 to regenerate MitoQ10. Consequently, MitoQ10 has a pro-oxidant role in intact cells, whereas it serves as an antioxidant when Complex I-derived superoxide generation is already elevated due to electron flow retardation.

Plecitá-Hlavatá L, Ježek J, Ježek P.: Pro-oxidant mitochondrial matrix-targeted ubiquinone MitoQ10 acts as anti-oxidant at retarded electron transport or proton pumping within Complex I. International Journal of Biochemistry and Cell Biology 2009; 41:1697-1707. IF=4.178

 

Author: plecita@biomed.cas.cz

01.1.2013 - BIOCEV
BIOTECHNOLOGY AND BIOMEDICINE CENTER OF THE ACADEMY OF SCIENCES AND CHARLES UNIVERSITY IN VESTEC

10.6.2010 - Award of the President of the Czech Granting Agency
RNDr. Ales Stuchlik PhD has been awarded by the Award of the President of the Czech Granting Agency

08.6.2010 - Prof. Bohuslav Ostadal, MD, PhD, has been awarded by the Gold Medal of Prof. Vaclav Libensky
– in the recognition of his lifetime scientific achievements in experimental cardiology

02.6.2010 - Otto Wichterle Premium
Martin Sládek, Ph.D. was awarded the Otto Wichterle Premium

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