Research topics
We use chemical genetics to dissect signalling pathways regulating cell fate during haematopoietic, mesenchymal and neuronal stem cell develoment. We also concentrate on nuclear hormone receptors as pleiotropic and potent effectors of self-renewal, cell proliferation and differentiation.
Current Grant Support
Ministry of Education, Youth and Sports of the Czech Republic, Center for Chemical Genetics (grant No. LC06077)
Ministry of Industry and Trade (grant No. FT-TA5/136)
European Comission (FP6 Integrated Project CRESCENDO Project No. 018652, FP7-INFRA Project EU-OPENSCREEN Project No: 261861 - European Infrastructure of Open Screening Platforms for Chemical Biology)
Grant Agency of the Czech Republic (grants No. GA310/08/0878, GA204/09/1905, GA305/10/0953)
Most important recent papers
(2008-present; names of the lab members underlined)Bartunek P, Karafiat V, Bartunkova J, Pajer P, Dvorakova M, Kralova J, Zenke M, Dvorak M. Impact of chicken thrombopoietin and its receptor c-Mpl on hematopoietic cell development. Exp Hematol 36(4): 495-505, 2008. (Pubmed) (DOI)
Gamper I, Koh KR, Ruau D, Ullrich K, Bartunkova J, Piroth D, Hacker C, Bartunek P, Zenke M. GAR22: a novel target gene of thyroid hormone receptor causes growth inhibition in human erythroid cells. Exp Hematol 37(5): 539-548.e4, 2009. (Pubmed) (DOI)
Zikova M, Corlett A, Bendova Z, Pajer P, Bartunek P. DISP3, a sterol-sensing domain-containing protein that links thyroid hormone action and cholesterol metabolism. Mol Endocrinol 23(4): 520-8, 2009. (Pubmed) (DOI)
Stachura DL, Reyes JR, Bartunek P, Paw BH, Zon LI, Traver D. Zebrafish kidney stromal cell lines support multilineage hematopoiesis. Blood 114(2): 279-89, 2009. (Pubmed) (DOI)
Sedlak D, Novak P, Kotora M, Bartunek P. Synthesis and evaluation of 17alpha-arylestradiols as ligands for estrogen receptor alpha and beta. J Med Chem 53(10): 4290-4, 2010. (Pubmed) (DOI)
Eignerova B, Sedlak D, Dracinsky M, Bartunek P, Kotora M. Synthesis and biochemical characterization of a series of 17alpha-perfluoroalkylated estradiols as selective ligands for estrogen receptor alpha. J Med Chem 53(19): 6947-53, 2010. (Pubmed) (DOI)