Research topics
Our research program is focused on:
(1) Early events during proximal T cell signalling: the characterization of lipid rafts translocation machinery and its functional elements
(2) The role of innate immune molecules in embryonic homeostasis
(3) The role of antimicrobial peptides in health and disease
(4) The immunomodulatory properties of neoglycoconjugates
Current Grant Support
GA AS CR (grant No. IAA500520707)
GA CR (310/09/2084)
Ministry of Education, Youth and Sports (grant No. 2B08066-4)
Ministry of Defense (grant No. 080188110R)
Most important recent papers
(2004-present; names of the lab members underlined)Filipp D, Leung BL, Zhang J, Veillette A, Julius M. Enrichment of lck in lipid rafts regulates colocalized fyn activation and the initiation of proximal signals through TCR alpha beta. J Immunol 172(7): 4266-74, 2004. (Pubmed)
Tribl B, Filipp D, Bodeker H, Yu P, Hammerrmuller I, McKerlie C, Keim V, Sibbald WJ. Pseudomonas pneumonia-mediated sepsis induces expression of pancreatitis-associated protein-I in rat pancreas. Pancreas 29(1): 33-40, 2004. (Pubmed)
Ljutic B, Carlyle JR, Filipp D, Nakagawa R, Julius M, Zuniga-Pflucker JC. Functional requirements for signaling through the stimulatory and inhibitory mouse NKR-P1 (CD161) NK cell receptors. J Immunol 174(8): 4789-96, 2005. (Pubmed)
Badour K, McGavin MK, Zhang J, Freeman S, Vieira C, Filipp D, Julius M, Mills GB, Siminovitch KA. Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells. Proc Natl Acad Sci U S A 104(5): 1593-8, 2007. (Pubmed) (DOI)
Filipp D, Moemeni B, Ferzoco A, Kathirkamathamby K, Zhang J, Ballek O, Davidson D, Veillette A, Julius M. Lck-dependent Fyn activation requires C terminus-dependent targeting of kinase-active Lck to lipid rafts. J Biol Chem 283(39): 26409-22, 2008. (Pubmed) (DOI)
Chlubnova I, Filipp D, Spiwok V, Dvorakova H, Daniellou R, Nugier-Chauvin C, Kralova B, Ferrieres V. Enzymatic synthesis of oligo-D-galactofuranosides and L-arabinofuranosides: from molecular dynamics to immunological assays. Organic and Biomolecular Chemistry (in press).
Reviews
Filipp D, Julius M. Lipid rafts: resolution of the "fyn problem"? Mol Immunol 41(6-7): 645-56, 2004. (Pubmed) (DOI)
Other results - Patents
United States Patent Application Serial No.: 08/746883
Title: B CELL ACTIVATION
Inventors: Michael H. Julius, Dominik Filipp, Kamel-Alizadeh-Khiavi
Filed: November 18,1996
Issued: July 25, 2000
International Patent Application: PCT/CA 99/00482 Pub. No.: WO 9961468
International Filing Date: May 27, 1999
Title: THE INDUCTION OF ANTIBIOTIC PEPTIDES BY LAIT/sCD14 PROTEIN
Applicants: Gemma Biotechnology Ltd
Michael H. Julius, Dominik Filipp
Teaching, lectures, public presentations
MB150P90E - Innate Immunity - Faculty of Science, Charles University, Prague - download presentations (password protected access)
Recent Advances in Immunology, Charles University, Prague.