Group of Nucleic Acid Chemistry

Antonín Holý, PhD., Head

DEPARTMENT OF NUCLEIC ACID CHEMISTRY
Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic


INTRODUCTION
PROJECTS
STAFF
SUPPORT
PAPERS
COLLABORATION
RESULTS
Realization of Research Results:
  • Duviragel™ (antiherpeticum), marketed by Léčiva Praha (Czech Republic) (1984)
  • original procedures for preparation of azidothymidine (anti-AIDS drug), produced in LACHEMA Brno (Czech Republic)
  • original antiviral drugs developed in USA by Gilead Sciences
    • Vistide™ (cidofovir) approved and marketed in USA a EU (1996) against CMV retinitis, also used fo treatment of malignizing papillomatoses, anogenital herpes, active against smallpox, monkeypox, etc.
    • Viread™ (tenofovir disoproxil) - novel anti-AIDS drug, approved 2001
    • Hepsera™ (adefovir dipivoxil) - novel drug against hepatitis B, approved 2002