DEPARTMENT OF NUCLEIC ACID CHEMISTRY
Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic
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Selected scientific papers (1998-2002):
Blindauer, C. A.; Holy, A.; Dvorakova, H.; and Sigel, H. Magnesium complexes of the antiviral 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) and of its 1-, 3-, and 7- deaza analogues in aqueous solution. J. Biol. Inorg. Chem. 1998, 3, 423-433. Hartmann, K.; Kuffer, M.; Balzarini, J.; Naesens, L.; Goldberg, M.; Erfle, V.; Goebel, F. D.; De Clercq, E.; Jindrich, J.; Holy, A.; Bischofberger, N.; and Kraft, W. Efficacy of the acyclic nucleoside phosphonates (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine (FPMPA) and 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against feline immunodeficiency virus. J. Acquir. Immune. Defic. Syndr. Hum. Retrovirol. 1998, 17, 120-128. Holy, A. Simple method for cleavage of phosphonic acid diesters to monoesters. Synthesis-Stuttgart. 1998, 1998, 381-385. Kulikowska, E.; Bzowska, A.; Holy, A.; Magnowska, L.; and Shugar, D. Antiviral acyclic nucleoside phosphonate analogues as inhibitors of purine nucleoside phosphorylase. Adv. Exp. Med. Biol. 1998, 431, 747-752. Meerbach, A.; Holy, A.; Wutzler, P.; De Clercq, E.; and Neyts, J. Inhibitory effects of novel nucleoside and nucleotide analogues on Epstein-Barr virus replication. Antivir. Chem. Chemother. 1998, 9, 275-282. Birkus, G.; Votruba, I.; Holy, A.; and Otova, B. 9-[2-(Phosphonomethoxy)ethyl]adenine diphosphate (PMEApp) as a substrate toward replicative DNA polymerases alpha, delta, epsilon, and epsilon*. Biochem. Pharmacol. 1999, 58, 487-492. Franek, F.; Holy, A.; Votruba, I.; and Eckschlager, T. Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines. Int. J. Oncol. 1999, 14, 745-752. Hocková, D.; Budesinsky, M.; Marek, R.; Marek, J.; and Holy, A. Regioselective preparation of N-7- and N-9-alkyl derivatives of N-6-[(Dimethylamino)methylene]adenine bearing an active methylene group and their further derivatization leading to alpha-branched acyclic nucleoside analogues. EUR. J. ORG. CHEM. 1999, 2675-2682. Holy, A.; Budesinsky, M.; Podlaha, J.; and Císarová, I. Synthesis of N1-[2-(phosphonomethoxy)ethyl] derivatives of 2,4-diaminopyrimidine and related acyclic nucleotide analogs. Collect. Czech. Chem. Commun. 1999, 64, 242-256. Holy, A.; Gunter, J.; Dvorakova, H.; Masojídková, M.; Andrei, G.; Snoeck, R.; Balzarini, J.; and De Clercq, E. Structure-antiviral activity relationship in the series of pyrimidine and purine N-[2-(2-phosphonomethoxy)ethyl] nucleotide analogues. 1. Derivatives substituted at the carbon atoms of the base. J. Med. Chem. 1999, 42, 2064-2086. Krejcová, R.; Horská, K.; Votruba, I.; and Holy, A. Isoenzymes of GMP kinase from L1210 cells: isolation and characterisation. Collect. Czech. Chem. Commun. 1999, 64, 559-570. Otová, B., Francová, K., Franek, F., Koutník, P., Votruba, I., Holy, A., Sladká, M., and Schramlová, J. 9-[2-(phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP) - a potential drug against hematological malignancies - induces apoptosis. Anticancer Res 1999, 19 [4B], 3173-3182. Smeijsters, L. J.; Franssen, F. F.; Naesens, L.; de Vries, E.; Holy, A.; Balzarini, J.; De Clercq, E.; and Overdulve, J. P. Inhibition of the in vitro growth of Plasmodium falciparum by acyclic nucleoside phosphonates. Int. J. Antimicrob. Agents 1999, 12, 53-61. Bobková, K., Otová, B., Marinov, I., Mandys, V., Panczak, A., Votruba, I., and Holy, A. Anticancer effect of PMEDAP - Monitoring of apoptosis. Anticancer Res. 2000, 20[2A], 1041-1047. Gómez-Coca, R. B.; Kapinos, L. E.; Holy, A.; Vilaplana, R. A.; González-Vilchez, F.; and Sigel, H. Metal ion-binding properties of 9-(4-phosphonobutyl)adenine (dPMEA), a sister compound of the antiviral nucleotide analogue 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA), and quantification of the equilibria involving four Cu(PMEA) isomers. J. Chem. Soc. Dalton Trans. 2000, 2077-2084. Hocek, M.; Holy, A.; Votruba, I.; and Dvorakova, H. Cytostatic 6-arylpurine nucleosides II. Synthesis of sugar- modified derivatives: 9-(2-deoxy-beta-D-erythro- pentofuranosyl)-, 9-(5-deoxy-beta-D-ribofuranosyl)- and 9-(2,3- dihydroxypropyl)-6-phenylpurines. Collection of Czechoslovak Chemical Communications 2000, 65, 1683-1697. Janeba, Z.; Holy, A.; and Masojidkova, M. Synthesis of acyclic nucleoside and nucleotide analogs derived from 6-amino-7H-purin-8(9H)-one. Collect. Czech. Chem. Commun. 2000, 65, 1126-1144. Krejcová, R., Horská, K., Votruba, I., and Holy, A. Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes. Biochem Pharmacol 2000, 60[12], 1907-1913. Meszarosova, K.; Holy, A.; and Masojidkova, M. Synthesis of acyclic adenine 8,N-anhydronucleosides. Collect. Czech. Chem. Commun. 2000, 65, 1109-1125. Zídek, Z., Franková, D., and Holy, A. Macrophage activation by antiviral acyclic nucleoside phosphonates in dependence on priming immune stimuli. Int J Immunopharmacol 2000, 22[12], 1121-1129. Bobková, K.; Gut, I.; Mandys, V.; Holý, A.; Votruba, I.; and Otová, B. Antitumour activity of a combined treatment with PMEDAP and docetaxel in the Prague inbred Sprague-Dawley/Cub rat strain bearing T-cell lymphoma. Anticancer Research 2001, 21, 2725-2731. Holy, A.; Otová, B.; Budesínsky, M.; Emerson, D.; and Wiles, M. E. O-phosphonatomethylcholine, its analogues, alkyl esters, and their biological activity. J MED CHEM 2001, 44, 4462-4467. Holý, A.; Votruba, I.; Tloustová, E.; and Masojídková, M. Synthesis and cytostatic activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N6-substituted adenines, -2,6-diaminopurines and related compounds. Collect. Czech. Chem. Commun. 2001, 66, 1545-1592. Janeba, Z. and Holy, A. Synthesis of 8-amino and 8-substituted amino derivatives of acyclic purine nucleoside and nucleotide analogs. Alkylation of 8-substituted purine bases. Nucleos Nucleot Nucleic Acids 2001, 20, 1103-1106. Janeba, Z.; Holý, A.; and Masojídková, M. Transformation of 8-[(2-hydroxyalkyl)sulfanyl]adenines to 6-amino-7H-purin-8(9H)-one derivatives. Collect. Czech. Chem. Commun. 2001, 66, 1393-1406. Zídek, Z.; Franková, D.; and Holy, A. Activation by 9-(R)-[2-(phosphonomethoxy)propyl]adenine of chemokine (RANTES, macrophage inflammatory protein 1) and cytokine (tumor necrosis factor alpha, interleukin-10 [IL-10], IL-1) production. Antimicrob Agents Chemother 2001, 45, 3381-3386. Balzarini, J.; Pannecouque, C.; DeClercq, E.; Aquaro, S.; Perno, C. F.; Egberink, H.; and Holy, A. Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates. Antimicrob Agents Chemother 2002, 46, 2185-2193. Cesnek, M., Holy, A., and Masojídková, M. 6-Guanidinopurine nucleosides and their analogues. Tetrahedron 2002, 58[15], 2985-2996. Holy, A.; Votruba, I.; Masojidkova, M.; Andrei, G.; Snoeck, R.; Naesens, L.; De Clercq, E.; and Balzarini, J. 6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with antiviral activity. J. Med. Chem. 2002, 45, 1918-1929. Snoeck, R., Holy, A., Dewolf-Peeters, C., VanDenOord, J., DeClercq, E., and Andrei, G. Antivaccinia activities of acyclic nucleoside phosphonate derivatives in epithelial cells and organotypic cultures. Antimicrob Agents Chemother 2002, 46[11], 3356-3361.
Hřebabecký, H.; Masojídková, M.; Holý, A.: |
