14.1.2011 - Different sensitivities of rat skeletal muscles and brain to novel anti-cholinesterase agents. Artic

K. A. Petrov, L. O. Yagodina, G. R. Valeeva, N. I. Lannik, A. D. Nikitashina, A. A. Rizvanov, V. V. Zobov, E. A. Bukharaeva, V. S. Reznik, E. E. Nikolsky, F. Vyskočil. Different sensitivities of rat skeletal muscles and brain to novel anti-cholinesterase

The rat respiratory muscle diaphragm has markedly lower sensitivity (more than 150 times) than the locomotor muscle extensor digitorum longus (EDL) to the new acetylcholinesterase (AChE) inhibitors, alkylammonium derivatives of 6-methyluracil (ADEMS). This study evaluated several possible reasons for differing sensitivity between the diaphragm and limb muscles and between the muscles and the brain.Our findings suggest that ADEMS compounds could be used for the selective inhibition of AChEs and as potential therapeutic or insecticide tools.

Author: Author: vyskocil@biomed.cas.cz

01.1.2013 - BIOCEV
BIOTECHNOLOGY AND BIOMEDICINE CENTER OF THE ACADEMY OF SCIENCES AND CHARLES UNIVERSITY IN VESTEC

01.6.2011 - RNDr. Lydie Plecitá-Hlavatá, Ph.D. and Mgr. Martin Horák, Ph.D. were awarded the Otto Wichterle Prem
RNDr. Lydie Plecitá-Hlavatá, Ph.D. and Mgr. Martin Horák, Ph.D. were awarded the Otto Wichterle Premium

25.5.2011 - PharmDr. Alena Sumová, DSc, has been awarded by the Lauberger Medal
PharmDr. Alena Sumová, DSc, has been awarded by the Lauberger Medal

25.5.2011 - Josef Zicha, M.D., DSc.,
has been awarded by Honourable membership in CzPA JEP

25.5.2011 - Prof. Bohuslav Ostadal, MD, PhD, has been awarded by the Purkyně Gold Medal of CzMA
Prof. Bohuslav Ostadal, MD, PhD, has been awarded by the Purkyně Gold Medal of CzMA