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Scientists
RNDr. Lenka Roubalová, PhD
RNDr. Jiří Novotný, CSc

Technical Assistants
Ing. Martin Chmátal, CSc.

Postgradual students
Mgr. Jana Brejchová
Ing. Kateřina Dlouhá
Mgr. Zdena Drastichová
Mgr. Dmytro Kagan
Mgr. Pavel Ostašov
Mgr. Hana Ujčíková
Ing. Miroslava Vošahlíková

Pregradual students
Bc. Alexandra Kračmarová
Bc. Lenka Ulrychová
Bc. Barbora Volfová

 


 
Department: Biochemistry of Membrane Receptors
Head: Petr Svoboda, Doc, PhD, DSc
    
Contact phone/fax number: 241062533
  241062137
  241062478
e-mail: svobodapbiomed.cas.cz
  241062533
    
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Research Topics:  

  1. Cellular and molecular mechanisms of desensitisation of hormone response. Agonist-induced subcellular redistribution of GPCR (G protein coupled receptors), agonist-induced subcellular redistribution of trimeric G proteins, soluble (cytosolic) forms of trimeric G proteins, detergent-resistant membrane domains (DRMs), hormone-induced changes in composition of DRMs, functional activity of trimeric G-proteins in plasma membrane compartments. This work is performed in selected cell lines stably expressing the specific types of GPCR, their cognate G proteins or the fusion proteins between GPCR and GFP (green fluorescent protein); in support from Glasgow University, Scotland, UK (Prof. Graeme Milligan).

  2. GABAB-R initiated signalling cascade in the brain; studies of isolated plasma membrane fractions, ontogenetic development; distribution in different brain areas.

  3. Beta-adrenergic signalling cascade in the heart muscle; changes induced by the long term agonist stimulation; hydrophobic membrane interactions.


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