Journal article: Journal of Comparative Neurology

Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats.

The aim of the study was to elucidate whether, when and where the transcripts of the clock genes Per1 and Per2 and the immediate early gene c-fos are spontaneously expressed and/or induced by light in the newborn retina. Endogenous expression of Per1 was detected in the neuroblastic retina, and Per2 expression was detected in the inner part of the neuroblastic retina from birth. Light pulses induced c-fos expression in ganglion cells from postnatal day 1 (P1). Light pulses also induced the expression of Per1 and c-fos in the retinal pigment epithelium until P3, but not afterward. Expression of Per2 was not photoresponsive until P10. The data demonstrate that the rat retina is photosensitive immediately after birth. During early postnatal development, the spatial distribution of spontaneous and light-induced gene expression within the retinal layers changes gradually.

Mateju K, Sumova A, Bendova Z.: Expression and light sensitivity of clock genes Per1 and Per2 and immediate-early gene c-fos within the retina of early postnatal Wistar rats. Journal of Comparative Neurology 2010; 518:3630-3644. IF=3.718

Author: sumovabiomed.cas.cz
 

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