Planetary scale 2-day waves were observed mainly in the January –February time zone in the southern hemisphere low latitude region. Meteor radar wind measurement at Cariri (7.5 S, 35.7 W) from the year 2005 to 2009 showed a distinct 2-day oscillation in the meridional wind with the amplitude of 20 to 50 m/s. The amplitude varied from year to year indicating inter-annual variability of the wave activity. During the same period, the height of ionospheric layer (h´F and constant frequency height) observed at Fortaleza (3.9 S, 38.4 W), near by the Cariri radar station, also showed a similar modulation, indicating influence of planetary 2-day waves in the ionosphere, too. The present work demonstrates simultaneous occurrence of 2-day oscillation in the mesosphere and ionosphere and to study possible effects in the equatorial ionosphere Spread F.