Mgr. et Mgr. Pavla Perlíková (Spáčilová)

e-mail: spacilova@uochb.cas.cz
phone: +420 220183343


Born 10. 3. 1984 in Ostrava (Czech Republic).

Scientific CV:
2003-2006 undergraduate study, Charles University in Prague - Faculty of Science, Bc. S. degree - specialization organic chemistry (supervisor Dr. Jan Šarek)
2004-2007 undergraduate study, Charles University in Prague - Faculty of Science, Bc. S. degree - specialization molecular biology and biochemistry (supervisor Associate Prof. Marián Hajdúch)
2006-2008 undergraduate study, Charles University in Prague - Faculty of Science, M. S. degree - specialization organic chemistry (supervisor RNDr. Jan Šarek, Ph.D.)
2007-2009 undergraduate study, Charles University in Prague - Faculty of Science, M. S. degree - specialization cell biology (supervisor Associate Prof. Marián Hajdúch)
since 2008 PhD study, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)

Professional membership:
Czech Chemical Society

Awards:
2008 Zentiva award for the best diploma thesis (1st position)
2011 Best oral presentation nominee (section chemistry), XI Interdisciplinary Meeting of Young Biologists, Chemists and Biochemists, Žďár nad Sázavou
2011 Best oral presentation, XV Symposium on Chemistry of Nucleic Acid Components, Český Krumlov


List of publications:

5.	Bourderioux, A.; Nauš, P.; Perlíková, P.; Pohl, R.; Pichová, I.; Votruba, I.; Džubák, P.; Konečný, P.; Hajdúch, M.; Stray, K.M.; Wang, T.; Ray, A.S.; Feng, J.Y.; Birkus, G.; Cihlar, T.; Hocek, M.: "Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines" J. Med. Chem. 2011, 54, 5498–5507.
4.	Nauš, P.; Perlíková, P.; Pohl, R.; Hocek, M.: "Sugar-modified derivatives of cytostatic 6-(het)aryl-7-deazapurine nucleosides: 2'-C-methylribonucleosides, arabinonucleosides and 2'-deoxy-2'-fluoroarabinonucleosides" Collect. Czech. Chem. Commun. 2011, 76, 957-988.
3.	Perlíková, P.; Pohl, R.; Votruba, I.; Shih, R.; Birkuš, G.; Cihlář, T.; Hocek, M.: "Phosphoramidate pronucleotides of cytostatic 6-aryl-7-deazapurine ribonucleosides" Bioorg. Med. Chem. 2011, 19, 229-242.
2.	Kvasnica, M.; Spacilova, P.; Budesinsky, M.; Hajduch, M.; Sarek, J.: "Oxidative Cleavage of 3beta-acetoxy-21-oxolup-18-en-28-oic Acid by Ruthenium Tetroxide" Chem. Nat. Compd. 2010, 46, 545-548.
1.	Spáčilová, P.; Nauš, P.; Pohl, R.; Votruba, I.; Snášel, J.; Zábranská, H.; Pichová, I.; Ameral, R.; Birkuš, G.; Cihlář, T.; Hocek, M.: "CycloSal-phosphate Pronucleotides of Cytostatic 6-(Het)aryl-7-deazapurine Ribonucleosides: Synthesis, Cytostatic Activity, and Inhibition of Adenosine Kinases" ChemMedChem 2010, 5, 1386–1396.

Patents:

2.	Šarek, J.; Spáčilová, P.; Hajduch, M.: "2-deoxyglykosidy triterpenoidů, způsob jejich přípravy a jejich použití jako léčivo" Patent Application PV 2008-732; 13th November 2008.
1.	Šarek, J.; Hajduch, M.; Svoboda, M.; Nováková, K.; Spáčilová, P.; Kubelka, T.; Biedermann, D.: "Method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, a soluble formulation of a pentacyclic or tetracyclic terpenoid and a pharmaceutical composition containing this soluble formulation" Patent Application PCT/CZ2007/000088.