Review articles in prestige journal Nature Genetics

Identification of distribution and functional impact of DNA copy number variation in the rat

The abundance and dynamics of copy number variants (CNVs) in mammalian genomes poses new challenges in the identification of their impact on natural and disease phenotypes. We used computational and experimental methods to catalogue CNVs in the rat and show that they encompass up to 1.5% of the rat genome and share important functional characteristics with human. Furthermore, by exploiting genetic and functional data available for rat recombinant inbred panels we were able to robustly establish the functional relationship of CNVs underlying 16 eQTLs. These characteristics make the rat an excellent model for studying phenotypic effects of structural variation in relation to human complex traits and disease.
V. Guryev, K. Saar, T. Adamovic, M. Verheul, S. A. A. C. van Heesch, S. Cook, M. Pravenec, T. Aitman, H. Jacob, J. D. Shull, N. Hubner, E. Cuppen: Distribution and functional impact of DNA copy number variation in the rat, Nature Genetics 40:538-545, 2008, IF=25.556

Author: pravenecbiomed.cas.cz
 

Journal article: Current Pharmaceutical Biotechnology
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Journal article: Behavioural Brain Research
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Journal article: Chronobiology International
Hepatic, Duodenal, and Colonic Circadian Clocks Differ in their Persistence under Conditions of Constant Light and in their Entrainment by Restricted Feeding.

Journal article: Amino Acids
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Journal article: Journal of Hypertension
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Journal article: Journal of Comparative Neurology
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Journal article: Epilepsia
Metabotropic glutamate receptors as a target for anticonvulsant and anxiolytic action in immature rats.

Journal article: Analytical and Bioanalytical Chemistry
Determination of insoluble avian eggshell matrix proteins.

Journal article: Journal of Biological Rhythms
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Tumor necrosis factor α sensitizes spinal cord TRPV1 receptors to the endogenous agonist N-oleoyldopamine

Journal article: Journal of Chromatography A
Non-enzymatic posttranslational modifications of bovine serum albumin by oxo-compounds investigated by high-performance liquid chromatography-mass spectrometry and capillary zone electrophoresis-mass spectrometry.

Journal article: Biochimica Et Biophysica Acta-Bioenergetics
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Journal article: Journal of Biological Chemistry
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Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase.

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Journal article: American Journal of Physiology-Heart and Circulatory Physiology
Pathways to embryonic heart failure.

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Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents.

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Spatial decisions and cognitive strategies of monkeys and humans based on abstract spatial stimuli in rotation test.

Review articles in prestige journal Nature Genetics
Identification of osteoglycin (Ogn) as a genetic determinant predisposing to left ventricular hypertrophy in rats, mice, and humans

Review articles in prestige journal Nature Genetics
Identification of single nucleotide polymorphisms and haplotype mapping in the rat

Review articles in prestige journal Nature Genetics
Identification of renal Cd36 as a genetic determinant of blood pressure and risk for hypertension

Journal article: Nature Genetics
Molecular-genetic basis of severe inherited mitochondrial disease – neonatal encephalo-cardiomyopathy.

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Chemical derivatives of docosahexaenoic acid (DHA) in the prevention and reversal of obesity in mice fed a high-fat diet

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n-3 fatty acids and rosiglitazone exerts additive effects on muscle glycogen synthesis in mice fed a high-fat diet

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Risperidone and ritanserin but not haloperidol block effect of dizocilpine on the active allothetic place avoidance task

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In vivo content of mitochondrial ATP synthase is controlled by expression of the gene encoding hydrophobic subunit c.

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Current informations about the FOXO subgroup of forkhead transcription factors and mechanism of regulation

Journal article: PLoS Computational Biology
Efficient coding principle confirmed for the sense of smell

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Evidence of impairment of muscarinic transmission in transgenic APPswe/PS1dE9 mouse model of Alzheimer´s disease.

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Induction of muscle thermogenesis by high-fat diet in mice: association with obesity-resistance

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The role of proline residues in the structure and function of human MT2 receptor.