Research topics
Signalling mechanism of G-protein-coupled receptors for major neurotransmitters. Structure-function relationship of metabotropic glutamate and GABAb receptors. Regulation of receptor signalling via interaction with associated proteins.
Current Grant Support
GA AS CR IAA400400621 (2006-2010)
Ministry of Education, Youth and Sports o the Czech Republic LC06063 "FLUMBIOL" (2006-2010)
GA AS CR IAA500390701 (2007-2011)
GACR GA 303/08/1591 (2008-2012)
Most important recent papers
(2004-present; names of the lab members underlined)Iacovelli L, Capobianco L, Iula M, Di Giorgi Gerevini V, Picascia A, Blahos J, Melchiorri D, Nicoletti F, De Blasi A. Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2). Mol Pharmacol 65(5): 1103-10, 2004. (Pubmed) (DOI)
Goudet C, Kniazeff J, Hlavackova V, Malhaire F, Maurel D, Acher F, Blahos J, Prezeau L, Pin JP. Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators. J Biol Chem 280(26): 24380-5, 2005. (Pubmed) (DOI)
Sinagra M, Verrier D, Frankova D, Korwek KM, Blahos J, Weeber EJ, Manzoni OJ, Chavis P. Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro. J Neurosci 25(26): 6127-36, 2005. (Pubmed) (DOI)
Brock C, Boudier L, Maurel D, Blahos J, Pin JP. Assembly-dependent surface targeting of the heterodimeric GABAB Receptor is controlled by COPI but not 14-3-3. Mol Biol Cell 16(12): 5572-8, 2005. (Pubmed) (DOI)
Hlavackova V, Goudet C, Kniazeff J, Zikova A, Maurel D, Vol C, Trojanova J, Prezeau L, Pin JP, Blahos J. Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR. EMBO J 24(3): 499-509, 2005. (Pubmed) (DOI)
Bertaso F, Lill Y, Airas JM, Espeut J, Blahos J, Bockaert J, Fagni L, Betz H, El-Far O. MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels. J Neurochem 99(1): 288-98, 2006. (Pubmed) (DOI)
Kumpost J, Syrova Z, Kulihova L, Frankova D, Bologna JC, Hlavackova V, Prezeau L, Kralikova M, Hruskova B, Pin JP, Blahos J. Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells. Neuropharmacology 55(4): 409-18, 2008. (Pubmed) (DOI)
Iacovelli L, Molinaro G, Battaglia G, Motolese M, Di Menna L, Alfiero M, Blahos J, Matrisciano F, Corsi M, Corti C, Bruno V, De Blasi A, Nicoletti F. Regulation of group II metabotropic glutamate receptors by G protein-coupled receptor kinases: mGlu2 receptors are resistant to homologous desensitization. Mol Pharmacol 75(4): 991-1003, 2009. (Pubmed) (DOI)
Pavek P, Pospechova K, Svecova L, Syrova Z, Stejskalova L, Blazkova J, Dvorak Z, Blahos J. Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene. Biochem Pharmacol 79(2): 277-87, 2010. (Pubmed) (DOI)
Pavlowsky A, Gianfelice A, Pallotto M, Zanchi A, Vara H, Khelfaoui M, Valnegri P, Rezai X, Bassani S, Brambilla D, Kumpost J, Blahos J, Roux MJ, Humeau Y, Chelly J, Passafaro M, Giustetto M, Billuart P, Sala C. A postsynaptic signaling pathway that may account for the cognitive defect due to IL1RAPL1 mutation. Curr Biol 20(2): 103-15, 2010. (Pubmed) (DOI)
Reviews
Pin JP, Kniazeff J, Binet V, Liu J, Maurel D, Galvez T, Duthey B, Havlickova M, Blahos J, Prezeau L, Rondard P. Activation mechanism of the heterodimeric GABA(B) receptor. Biochem Pharmacol 68(8): 1565-72, 2004. (Pubmed) (DOI)