Research Topics
Retroviruses, retroviral vectors, receptors for retroviruses, latency and persistence of retroviruses, endogenous retroviruses, retrotransposons, epigenetics, src-oncogene, transgenesis in chicken, chicken genomics.
Current grant support
Ministry of Education, Youth and Sports of the Czech Republic (Center of Cellular Invasiveness in Embryonic Development and Tumour Metastasis, grant No.: LC06061)
Grant Agency of the Czech Republic (grants Nos: 204/08/P616, 301/09/2031, 301/09/P667, P502/10/1651)
European Committee (6th FP Project XENOME)
Most important recent papers
(2005-present; names of the lab members underlined)Elleder D, Stepanets V, Melder DC, Senigl F, Geryk J, Pajer P, Plachy J, Hejnar J, Svoboda J, Federspiel MJ. The receptor for the subgroup C avian sarcoma and leukosis viruses, Tvc, is related to mammalian butyrophilins, members of the immunoglobulin superfamily. J Virol 79(16): 10408-19, 2005. (Pubmed) (DOI)
Matouskova M, Blazkova J, Pajer P, Pavlicek A, Hejnar J. CpG methylation suppresses transcriptional activity of human syncytin-1 in non-placental tissues. Exp Cell Res 312(7): 1011-20, 2006. (Pubmed) (DOI)
Trefil P, Micakova A, Mucksova J, Hejnar J, Poplstein M, Bakst MR, Kalina J, Brillard JP. Restoration of spermatogenesis and male fertility by transplantation of dispersed testicular cells in the chicken. Biol Reprod 75(4): 575-81, 2006. (Pubmed) (DOI)
Prukova D, Vernerova Z, Pilcik T, Stepanets V, Indrova M, Geryk J, Plachy J, Hejnar J, Svoboda J. Differences in pathogenicity among strains of the same or different avian leukosis virus subgroups. Avian Pathol 36(1): 15-27, 2007. (Pubmed) (DOI)
Kalina J, Senigl F, Micakova A, Mucksova J, Blazkova J, Yan H, Poplstein M, Hejnar J, Trefil P. Retrovirus-mediated in vitro gene transfer into chicken male germ line cells. Reproduction 134(3): 445-53, 2007. (Pubmed) (DOI)
Reinisova M, Senigl F, Yin X, Plachy J, Geryk J, Elleder D, Svoboda J, Federspiel MJ, Hejnar J. A single-amino-acid substitution in the TvbS1 receptor results in decreased susceptibility to infection by avian sarcoma and leukosis virus subgroups B and D and resistance to infection by subgroup E in vitro and in vivo. J Virol 82(5): 2097-105, 2008. (Pubmed) (DOI)
Reinisova M, Pavlicek A, Divina P, Geryk J, Plachy J, Hejnar J. Target site preference of subgroup C Rous sarcoma virus integration into the chicken DNA. The Open Genomics J. 1: 6-12, 2008. (FullText)
Senigl F, Plachy J, Hejnar J. The core element of a CpG island protects avian sarcoma and leukosis virus-derived vectors from transcriptional silencing. J Virol 82(16): 7818-27, 2008. (Pubmed) (DOI)
Blazkova J, Trejbalova K, Gondois-Rey F, Halfon P, Philibert P, Guiguen A, Verdin E, Olive D, Van Lint C, Hejnar J, Hirsch I. CpG methylation controls reactivation of HIV from latency. PLoS Pathog 5(8): e1000554, 2009. (Pubmed) (DOI)
Pajer P, Karafiat V, Pecenka V, Prukova D, Dudlova J, Plachy J, Kasparova P, Dvorak M. Industasis, a promotion of tumor formation by nontumorigenic stray cells. Cancer Res 69(11): 4605-12, 2009. (Pubmed) (DOI)
Morkovsky L, Storchova R, Plachy J, Ivanek R, Divina P, Hejnar J. The Chicken Z Chromosome Is Enriched for Genes with Preferential Expression in Ovarian Somatic Cells. J Mol Evol. 2009 Dec 27. [Epub ahead of print] (Pubmed) (DOI)
Plachy J, Kotab J, Divina P, Reinisova M, Senigl F, Hejnar J. Proviruses Selected for High and Stable Expression of Transduced Genes Accumulate in Broadly Transcribed Genome Areas. J Virol. 2010 Feb 10. [Epub ahead of print] (Pubmed) (DOI)
Reviews
Svoboda J. Foundations in cancer research. The turns of life and science. Adv Cancer Res 99: 1-32, 2008. (Pubmed) (DOI)
Other results
Patent 300377 ze dne 26.3. 2009, ÚPV Praha: Regulační genový element obsahující promotor/zesilovač chráněný před methylací DNA a umlčením genové exprese.