The data of igsg-TEC and UKMO data are used to analyze the large scale disturbances in the ionosphere and middle atmosphere from 2002 to 2009. In most years, the 6.5-day disturbance can be found in the ionosphere and middle atmosphere with wavenumber one around spring and autumn equinoxes. The amplitudes of the distubances in ionosphere and middle atmosphere are highly related. The strongest disturbances are all in 2004. The vertical drift of plasma also have similiar variations around two equinoxes. The results show the quasi-6.5-day disturbances in the ionosphere maybe resulted from the quasi-6.5-day waves in the middle atmosphere through interactions between atmosphere and plasma electric fields.