Main research topics of the department

- Age-dependent interactions of genetic and environmental factors in the pathogenesis of  experimental hypertension.
 - Search for genes responsible for high blood pressure and metabolic disturbances in spontaneous and saltinduced forms of hypertension.
 - Alterations of particular cellular ion transport mechanisms in genetic and experimental hypertension.
-  The role of disturbances in intracellular calcium and pH regulations as well as in membrane fluidity and lipid metabolism in pathogenesis of genetic and experimental hypertension.
 -Sex-dependent differences in growth and calcium handling of smooth muscle cells isolated from hypertensive or normotensive animals.
 - The role of vasoactive systems in the maintenance of genetic and experimental hypertension.
-  Interaction of oxygen free radicals and nitric oxide in the pathogenesis of agedependent experimental hypertension.
 - Metabolism of high density lipoproteins (HDL) in relation to composition of HDL subclasses and cholesterol esterification by lecithin cholesterol acyltransferase.
 - Relationship between renal failure and plasma lipid profile in human.
- Evaluation of antioxidant status with special attention to the age of experimental animals, study of antioxidant protective effect of carnitine and other agents which could improve the antioxidant status of the organism.
 
 

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