The 22nd Annual Rudolf Brdička Memorial Lecture was held on June 21 in Brdička hall.

Enrico Gratton
University of California, Irvine
Professor of Biomedical Engineering and Physics


Nanoimaging technique with high time and spatial resolution:
Mechanisms of translocation through the nuclear pore complex


Abstract:
In eukaryotic cells, all traffic between the nucleus and the cytoplasm is regulated by the nuclear pore complex. Much is known about the structure of the nuclear pore complex. However, the mechanism that allows very large particles to pass through the pore is still debated. In this talk I will discuss current models proposed for the opening and closing of the pore. I will present recent experimental evidence from my lab which poses strong constraints about possible mechanisms. I will describe a nanoimaging technique that has a very high time and spatial resolution. Using this technique we can observe the translocation of particles in great detail and reveal possible mechanisms of action of the nuclear pore complex.

More information about Rudolf Brdička Memorial Lecture 2012 find in invitation (pdf).

Some photos from lecture...






(photos: K.Stejskalová, archive JHI)