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Brain superoxide anion formation in immature rats during seizures: Protection by selected compounds.
The present findings provide the evidence of oxidative stress in brain of immature rats during seizures induced by DL-homocysteic acid. The enhanced O2 .- production was significantly attenuated or completely prevented by substances providing an anticonvulsant effect and by selected SOD mimetics. The increased O2 .- generation precedes neuronal degeneration and may thus play a causative role in neuronal injury.
Folbergrová J, Otáhal J, Druga R.: Brain superoxide anion formation in immature rats during seizures: Protection by selected compounds. Experimental Neurology 2012; 233:421-429. IF=4.436
Author: folbergr biomed.cas.cz
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