1. Links between energy metabolism, lipid metabolism and cell proliferation in adipose tissue; and influence of adipose tissue metabolism on body fat content and insulin sensitivity.

2. Dietary and pharmacological modulations of white adipose tissue metabolism.

3. Mechanisms involved in the effects of n-3 long-chain polyunsaturated fatty acids of marine origin (omega 3) on inflammation, energy metabolism and insulin sensitivity, namely with respect to prevention and treatment of obesity and its comorbidities (i.e. "metabolic syndrome").

4. Role of lipid mediators (eicosanoids, resolvines, and protectines), endocannabinoids, and the adiponectin-AMPK axis in the effects of omega 3 on metabolic diseases associated with obesity and aging, and on cell proliferation.

5. Use of omega 3 adjuvants in combined interventions to improve efficacy of the treatment of metabolic syndrome.

6. Complex metabolomics biomarkers of propensity to obesity and associated diseases.

Publications

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Last update: July 2012