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A new epigenetic marker: The replication-coupled, cell cycle-dependent, dual modification of the histone H4 tail.
By acetylation of H4K16 during S-phase, the early replicating chromatin domains acquire the H4K16ac-K20me2 epigenetic label that persists on the chromatin throughout mitosis and become deacetylated during early G1-phase of the next cell cycle.
Fidlerová H, Kalinová J, Blechová M, Velek J, Raska I.: A new epigenetic marker: The replication-coupled, cell cycle-dependent, dual modification of the histone H4 tail. Journal of Structural Biology 2009; 167:76-82. IF=4.059
Author: hfidllf1.cuni.cz
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