Michael Downey, M.Sc.

e-mail: downey@uochb.cas.cz
phone: +420 220 183 343


Born 14.4.1986 in Calgary (Canada).

Scientific CV:
2004-2009 undergraduate study, University of Alberta, BSc degree - Specialisation Pharmacology, Industrial Internship Program (Supervisor: Dr. Christopher Cairo)
2009-2012 MSc study, University of Alberta, MSc degree - Specialisation Chemical Biology, (Supervisor: Dr. Christopher Cairo)
since 2013 PhD study, Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic (supervisor Dr. M. Hocek)

Professional membership:
Canadian Society for Chemistry

List of publications:

4.	Downey, A.M.; Richter, C.; Pohl, R.; Mahrwald, R.; Hocek, M.: "Direct One-Pot Synthesis of Nucleosides from Unprotected or 5-O-Monoprotected D-Ribose" Org. Lett. 2015, 17, 4604–4607.
3.	Downey, A.M.; Cairo, C.W.: "Synthesis of α-brominated phosphonates and their application as phosphate bioisosteres" Med. Chem. Commun. 2014, 5, 1619-1633.
2.	Downey, A.M.; Cairo, C.W.: "α-Bromophosphonate analogs of glucose-6-phosphate are inhibitors of glucose-6-phosphatase" Carbohydr. Res. 2013, 381, 123-132.
1.	Tulsi, N.S.; Downey, A.M.; Cairo, C.W.: "A protected L-bromophosphonomethylphenylalanine amino acid derivative (BrPmp) for synthesis of irreversible protein tyrosine phosphatase inhibitors" Bioorg. Med. Chem. 2010, 18, 8679-8686.

Patents:

1.	Cairo, C.W.; Tulsi N.S.; Downey, A.M.: "Preparation of bromophosphonomethylphenylalanine derivatives as irreversible inhibitors of protein tyrosine phosphatases" Patent Application PCT Int. Appl. 2011, WO 2011106898 (A1) 2011-09-09.