Isabell Graf, Simon Fraser University, Burnaby, Canada, e-mail: imgraf@sfu.ca, grafisab@gmail.com; Malte A. Peter, Institute of Mathematics, University of Augsburg, Universitätsstrasse 14, 86159 Augsburg, Germany and Augsburg Centre for Innovative Technologies, University of Augsburg, 86135 Augsburg, Germany, e-mail: malte.peter@math.uni-augsburg.de
Abstract: In the context of periodic homogenization based on two-scale convergence, we homogenize a linear system of four coupled reaction-diffusion equations, two of which are defined on a manifold. The system describes the most important subprocesses modeling the carcinogenesis of a human cell caused by Benzo-[a]-pyrene molecules. These molecules are activated to carcinogens in a series of chemical reactions at the surface of the endoplasmic reticulum, which constitutes a fine structure inside the cell. The diffusion on the endoplasmic reticulum, modeled as a Riemannian manifold, is described by the Laplace-Beltrami operator. For the binding process to the surface of the endoplasmic reticulum, different scalings with powers of the homogenization parameter are considered. This leads to three qualitatively different models in the homogenization limit.
Keywords: periodic homogenization; two-scale convergence; carcinogenesis; reaction-diffusion system; surface diffusion
Classification (MSC 2010): 35B27, 35K51, 35K58, 92C37
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