EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Picolyl amides of betulinic acid as antitumor agents causing tumor cell apoptosis

Bildziukevich U., Rárová L., Šaman D., Wimmer Z.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 145 : 41-50 , 2018
Klíčová slova:

5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases Record contains structures

Vymetalová L., Havlíček L., Šturc A., Skrášková Z., Jorda R., Pospíšil T., Strnad M., Kryštof V.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 110 : 291-301 , 2016
Klíčová slova: Cyclin-dependent kinase Inhibitor Selectivity Bioisostere

Prospective performance evaluation of selected common virtual screening tools. Case study: Cyclooxygenase (COX) 1 and 2.

Kaserer T., Temml V., Kutil Z., Vaněk T., Landa P., Schuster D.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 96 : 445-457 , 2015
Klíčová slova: Method comparison; Docking; Pharmacophore modeling; Shape-based modeling; 2D similarity-based search; Cyclooxygenas

Synthesis and biological activity of 8-azapurine and pyrazolo[4,3-d]pyrimidine analogues of myoseverin

Kryštof, Vladimír; Moravcová, Daniela; Paprskářová, Martina; Barbier, P.; Peyrot, V.; Hlobilková, Alice; Havlíček, Libor; Strnad, Miroslav
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 41 : 1405-1411 , 2006
Klíčová slova: Myoseverin; Purine; Tubulin