prof. Jiří Homola, Ph.D., DSc.

Position: 
Deputy Director for Science; Team leader
Team: 
Optical Biosensors
Phone: 
+420 266 773 543
E-mail: 
homola@ufe.cz
Location: 
Main building of IPE, Praha 8 - Kobylisy
Room: 
II/24

Other Appointments

Professor - Faculty of Mathematics and Physics, Charles University, Prague, Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University in Prague

Affiliate Professor - University of Washington, Seattle (USA)

Adjunct Professor - University of Oulu, Oulu (Finland)

Education

2009: DSc - Academy of Sciences of the Czech Republic, Prague 

1993: PhD - Academy of Sciences of the Czech Republic, Prague 

1988: MS - Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University, Prague

Awards and honors

2015    Member of the Learned Society, Czech Republic

2014    Award for Outstanding Research of the Ministry of Education, Youth and Sports of the Czech Republic, Czech Republic

2012    Fellow of SPIE, SPIE - The International Society for Optical Engineering, USA

2011    Praemium Academiae, Academy of Sciences of the Czech Republic, Prague

2009    Czech Head for Inventiveness, Czech Republic, Prague

2006    Roche Prize for Sensor Technology, Germany, Tuebingen

2003    Otto Wichterle Award, Academy of Sciences of the Czech Republic, Prague

2003    Senior Member of IEEE, IEEE - Institute of Electrical and Electronics Engineers, USA

Research interests

photonics, biophotonics, optical sensors and biosensors

Teaching

Optical Sensors (NBCM305), Faculty of Mathematics and Physics, Charles University, Prague

Optical Sensors (12OSE), Faculty of Nuclear Sciences and Physical Engineering, Czech Technical University, Prague

Publications

Books:

  1. J. Homola (editor): Surface Plasmon Resonance Based Sensors, Springer, 2006.
  2. F. Baldini, A. N. Chester, J. Homola, and S. Martellucci (editors): Optical Chemical Sensors, NATO Science Series II, Vol. 224, Springer, 2006.

Book chapters:

  1. P. Adam, M. Piliarik, H. Šípová, T. Špringer, M. Vala, J. Homola: Surface Plasmons for Biodetection, in Photonic Sensing: Principles and Applications for Safety and Security Monitoring, editors W. J. Bock, J., X. Gaozhi, John Wiley & Sons, 2012, 1-58.
  2. M. Piliarik, H. Vaisocherová, J. Homola: Surface Plasmon Resonance Biosensing, in Biosensors and Biodetection, Methods in Molecular Biology, Vol. 503, editors A. Rasooly, K. E. Herold, Humana Press, 2009, 65-88.
  3. A. D. Taylor, J. Ladd, J. Homola, and S. Jiang, Surface Plasmon Resonance (SPR) Sensors for the Detection of Bacterial Pathogens, in Principles of Bacterial Detection: Biosensors, Recognition Receptors and Microsystems, editors M. Zourob, S. Elwary, and A. Turner, Springer, 81-106, 2008.
  4. J. Homola, S. S. Yee, D. Myszka: Surface plasmon biosensors, in Optical Biosensors: Today and Tomorrow (2nd Edition), editors F. S. Ligler, C. R. Taitt, Elsevier, 2008, 185-242.
  5. J. Homola: Surface plasmon resonance (SPR) biosensors and their applications in food safety and security, in Frontiers in Planar Lightwave Circuit Technology: Design, Simulation, and Fabrication, editors S. Janz, J. Čtyroký, and S. Tanev, Springer, 2006, 101-118.
  6. J. Homola: Surface Plasmon Resonance Biosensors for Food Safety, in Optical Sensors: Industrial, Environmental and Diagnostic Applications, editors R. Narayanaswamy and O.S. Wolfbeis, Springer, 2004, 145-172.
  7. J. Homola, S. S. Yee, D. Myszka: Surface plasmon biosensors, in Optical Biosensors: Present and Future, editors F. S. Ligler, C. R. Taitt, Elsevier Science, 2002, 207-253.

Journal papers:

    1. J. Slabý, J. Homola, Performance of label-free optical biosensors: What is figure of merit (not) telling us?, Biosensors and Bioelectronics, Volume 212, 114426 (2022). 
    2. Y. Wang, A. Kálosi, Y. Halahovets, I. Romanenko, J. Slabý, J. Homola, J. Svoboda, A. de los Santos Pereira, O. Pop-Georgievski, Grafting density and antifouling properties of poly[N-(2-hydroxypropyl) methacrylamide] brushes prepared by “grafting to” and “grafting from”, Polymer Chemistry 13, 3815-3826 (2022). 
    3. H. Altug, SH. Oh, S.A. Maier, J. Homola: Advances and applications of nanophotonic biosensors. Nat. Nanotechnol. 17, 5–16 (2022).
    4. T.  Špringer, Z. Krejčík, J. Homola: Detecting attomolar concentrations of microRNA related to myelodysplastic syndromes in blood plasma using a novel sandwich assay with nanoparticle release, Biosensors and Bioelectronics 194, 113613 (2021). 
    5. A. Ligasová, I. Rosenberg, M. Bocková, J. Homola, K. Koberna: Anchored linear oligonucleotides: the effective tool for the real-time measurement of uracil DNA glycosylase activity, Open Biol. 11, 210136 (2021).
    6. J. Slabý, M. Bocková, J. Homola: Plasmonic biosensor based on a gold nanostripe array for detection of microRNA related to myelodysplastic syndromes, Sensors and Actuators B: Chemical, 130629 (2021).
    7. H. Šípová Jungová, L. Jurgová, E. Hemmerová, J. Homola: Interaction of Tris with DNA molecules and carboxylic groups on self-assembled monolayers of alkanethiols measured with surface plasmon resonance, Applied Surface Science, 546, 148984 (2021). 
    8. E. Hemmerová, T. Špringer, Z. Krištofiková and J. Homola: Ionic environment affects biomolecular interactions of amyloid-β: SPR biosensor study, International Journal of Molecular Sciences, 21, 9727 (2020).
    9. E. Hemmerová, T. Špringer, Z. Krištofiková, J. Homola: Study of biomolecular interactions of mitochondrial proteins related to Alzheimer's disease: toward multi-interaction biomolecular processes, Biomolecules, 10, Article Number: 1214 (2020).
    10. T. Špringer, E. Hemmerová, G. Finocchiaro, Z. Krištofiková, M. Vyhnálek, J. Homola: Surface plasmon resonance biosensor for the detection of tau-amyloid beta complex, Sensors and Actuators B-Chemical, 316, Article Number: 128146 (2020).
    11. D. Kotlarek, S. Fossati, P. Venugopalan, N. G. Quilis, J. Slabý, J. Homola, M. Lequeuxe, F. Amiard, M. Lamy de la Chapelle, U.  Jonas, J.  Dostálek: Actuated plasmonic nanohole arrays for sensing and optical spectroscopy applications, Nanoscale, 12, 9756 –9768 (2020). 
    12. Z. Krištofiková, T. Špringer, E. Gedeonová, A. Hofmannová, J. Ríčný, L. Hromadková, M. Vyhnálek, J. Laczo, T. Nikolai, J. Hort, T. Petrásek, A. Stuchlík, K. Valeš, J. Klaschka,  J. Homola: Interactions of 17β-Hydroxysteroid Dehydrogenase Type 10 and Cyclophilin D in Alzheimer's Disease, Neurochemical Research, 45, 915–927(2020).
    13. N. S. Lynn, T. Špringer, J. Slabý, B. Špačková, M. Gráfová, M. L. Ermini, J. Homola: Analyte transport to micro- and nano-plasmonic structures, Lab on a Chip, 19, 4117-4127 (2019).
    14. O. Pastva, L. Chrastinová, M. Bocková, R. Kotlín, J. Suttnar, A. Hlaváčková, J. Štikarová, E.  Ceznerová, J. Čermák, J. Homola, J. E. Dyr: Hsp70 trap assay for detection of misfolded subproteome related to Myelodysplastic syndromes, Analytical Chemistry, 91, 14226-14230 (2019).
    15. E. Hemmerová, T. Špringer, Z. Krištofiková, J. Homola: In vitro study of interaction of 17β-hydroxysteroid dehydrogenase type 10 and cyclophilin D and its potential implications for Alzheimer’s disease, Scientific Reports, 9, Article number 16700 (2019). 
    16. L. Chrastinová, O. Pastva, M. Bocková, N. S. Lynn, P. Šácha, M. Hubálek, J. Suttnar, R. Kotlín, J. Štikarová, A. Hlaváčková, K. Pimková, J. Čermák, J. Homola, and J. E. Dyr: A new approach for the diagnosis of myelodysplastic syndrome subtypes based on protein interaction analysis, Scientific Reports, 9, Article number 12647 (2019).
    17. X. Chadtová Song, E. Gedeonová, J. Homola: Surface plasmon resonance biosensor for the ultrasensitive detection of bisphenol A, Analytical and Bioanalytical Chemistry, 411, 5655–5658 (2019).
    18. M. Bocková, J. Slabý, T. Špringer, J. Homola: Advances in surface plasmon resonance imaging and microscopy and their biological applications, Annual Review of Analytical Chemistry, 12, 151–176 (2019).
    19. B. Špačková, M. L Ermini, J. Homola, High-performance biosensor exploiting a light guidance in sparse arrays of metal nanoparticles, Optics Letters, 44, 1568-1571 (2019).
    20. H. Šípová-Jungová, L. Jurgová, K., Mrkvová, N. S. Lynn, B. Špačková, J. Homola: Biomolecular charges influence the response of surface plasmon resonance biosensors through electronic and ionic mechanisms, Biosensors and Bioelectronics, 126, 365-372 (2019).
    21. M. L. Ermini, X. Chadtova Song, T. Špringer, J. Homola: Peptide functionalization of gold nanoparticles for the detection of carcinoembryonic antigen in blood plasma via SPR-based biosensor, Frontiers in Chemistry, doi: 10.3389/fchem.2019.00040 (2019).
    22. A. R. Ferhan, B. Špačková, J. A. Jackman, G. J. Ma, T. N. Sut, J. Homola, and N.-J. Cho: Nanoplasmonic ruler for measuring separation distance between supported lipid bilayers and oxide surfaces, Analytical Chemistry, 90, 12503-12511 (2018).
    23. B. Špačková, N. S. Lynn Jr., J. Slabý, H. Šípová, J. Homola: A route to superior performance of a nanoplasmonic biosensor: consideration of both photonic and mass transport aspects, ACS Photonics, 5, 1019-1025 (2018).
    24. A. Giorgini, S. Avino, P. Malara, R. Zullo, P. De Natale, K. Mrkvová, J. Homola, G. Gagliardi, Surface-plasmon optical-heterodyne clock biosensor, Sensors & Actuators B, 273, 336-341 (2018).
    25. N. S. Lynn Jr., J. Homola: Microfluidic analyte transport to nanorods for photonic and electronic applications, Chemistry - A European Journal, 24, 12031-12036 (2018).
    26. H. Lísalová, E. Brynda, M. Houska, I. Víšová, K. Mrkvová, X. Chadtová Song, E. Gedeonová, F. Surman, T. Riedel, O. Pop-Georgievski, and J. Homola: Ultralow-fouling behavior of biorecognition coatings based on carboxy-functional brushes of zwitterionic homo- and copolymers in blood plasma: functionalization matters, Analytical Chemistry, 89, 3524-3531 (2017).
    27. T. Špringer, X. Chadtová Song, M. L. Ermini, J. Lamačová, J. Homola: Functional gold nanoparticles for optical affinity biosensing, Analytical and Bioanalytical Chemistry, 409, 4087–4097 (2017).
    28. M. Kalousová, S. Dusilová-Sulková, A. Kuběna, O. Zakiyanov, K Levová, M. Bocková, E. Gedeonová, X. Chadtová Song, M. L. Ermini, T. Špringer, J. Homola, V. Tesař, and T. Zima: Pregnancy-associated plasma protein A2 in hemodialysis patients: significance for prognosis, Kidney and Blood Pressure Research, 42, 509-518 (2017).
    29. N. S. Lynn Jr., J. Homola: (Bio)sensing using nanoparticle arrays: on the effect of analyte transport on sensitivity, Analytical Chemistry, 88, 12145–12151 (2016).
    30. B. Špačková, P. Wrobel, M. Bocková, J. Homola: Optical biosensors based on plasmonic nanostructures: a review, Proceedings of the IEEE, 104, 2380–2408 (2016).
    31. D. Galvan, B. Špačková, J. Slabý, F. Sun, Y-H. Ho, J. Homola, and Q. Yu: Surface-Enhanced Raman Scattering (SERS) on Gold Nanohole Arrays in Symmetrical Dielectric Environments Exhibiting Electric Field Extension, Journal of Physical Chemistry C, 120, 25519–25529 (2016). 
    32. C. Bessa-Pereira, M. Bocková, R. F. Santos, A. M. Santos, M. Martins de Araújo, L. Oliveira, J. Homola, A. M. Carmo: The scavenger receptor SSc5D physically interacts with bacteria through the SRCR-containing N-terminal domain, Frontiers in Immunology, 7, Article 416, 1-9 (2016).
    33. H. Vaisocherová-Lísalová, F. Surman, I. Víšová, M. Vala, T. Špringer, M. L. Ermini, H. Šípová, P. Šedivák, M. Houska, T. Riedel, O. Pop-Georgievski, E. Brynda, J. Homola: Copolymer Brush-Based Ultralow-Fouling Biorecognition Surface Platform for Food Safety, Analytical Chemistry, 88, 10533–10539 (2016).
    34. M. Bocková, X. Xue Chadtová Song, E. Gedeonová, K. Levová, M. Kalousová, T. Zima, J. Homola: Surface plasmon resonance biosensor for detection of pregnancy associated plasma protein A2 in clinical samples, Analytical and Bioanalytical Chemistry, 408, 7265–7269 (2016).
    35. V. Peksa, P. Lebrušková, H. Šípová, M. Procházka, J. Bok, J. Štěpánek, J. Homola: Testing gold nanostructures fabricated by hole-mask colloidal lithography as potential substrates for SERS sensors: sensitivity, signal variability, and the aspect of adsorbate deposition, Physical Chemistry Chemical Physics, 18, 19613-19620 (2016).
    36. M. Vala, J. Homola: Multiple beam interference lithography: A tool for rapid fabrication of plasmonic arrays of arbitrary shaped nanomotifs, Optics Express, 24, 15656-15665 (2016).
    37. J. A. Jackman, B. Špačková, E. Linardy, M. C. Kim, B. Yoon, J. Homola, and N.-J. Cho: Nanoplasmonic ruler to measure lipid vesicle deformation, Chemical Communications, 52, 76-79 (2016).
    38. H. Vaisocherová-Lísalová, I. Víšová, M. L. Ermini, T. Špringer, X. Song, J. Mrázek, J. Lamačová, N. S. Lynn Jr., P. Šedivák, and J. Homola: Low-fouling surface plasmon resonance biosensor for multi-step detection of foodborne bacterial pathogens in complex food samples, Biosensors and Bioelectronics, 80, 84–90 (2016).
    39. N. S. Lynn, M. Bocková, P. Adam, J. Homola: Biosensor enhancement using grooved micromixers: part II, experimental studies, Analytical Chemistry, 87, 5524-5530 (2015).
    40. N. S. Lynn, J. Homola: Biosensor enhancement using grooved micromixers: part I, numerical studies, Analytical Chemistry, 87, 5516–5523 (2015).
    41. H. Vaisocherová, E. Brynda, J. Homola: Functionalizable Low-fouling coatings for label-free biosensing in complex biological media: advances and applications, Analytical and Bioanalytical Chemistry, 407, 3927-3953 (2015).
    42. M. Bocková, T. Špringer, I. Nečasová, J. Nunvar, B. Schneider, and J. Homola: Monitoring RAYT activity by surface plasmon resonance biosensor, Analytical and Bioanalytical Chemistry, 407, 3985-3993 (2015).
    43. H. Vaisocherová, I. Víšová, M. Bocková, T. Špringer, M. L. Ermini, X. Song, Z. Krejčík, L. Chrastinová, O. Pastva, K. Pimková, M. Dostálová Merkerová, J. E. Dyr, and J. Homola: Rapid and sensitive detection of multiple MicroRNAs in cell lysate by low-fouling surface plasmon resonance biosensor, Biosensors and Bioelectronics, 70, 226–231 (2015).
    44. N. Sharma, C. Petri, U. Jonas, M. Bach, G. Tovar, K. Mrkvová, M. Vala, J. Homola, W. Knoll, J. Dostálek: Molecularly imprinted polymer waveguides for direct optical detection of low molecular weight analytes, Macromolecular Chemistry and Physics, 215, 2295–2304 (2014)
    45. T. Špringer, M. L. Ermini, B. Špačková, J. Jabloňků, J. Homola: Enhancing sensitivity of SPR biosensors by functionalized gold nanoparticles: size matters, Analytical Chemistry, 86, 10350−10356 (2014)
    46. P. Kvasnička, J. Homola: Convenient method of micrometer-scale excitation of propagating surface plasmons by a focused laser beam, Plasmonics, 9, 737–739 (2014)
    47. B. Špačková, P. Lebrušková, H. Šípová, P. Kwiecien, I. Richter, J. Homola: Ambiguous refractive index sensitivity of Fano resonance on an array of gold nanoparticles, Plasmonics, 9, 729–735 (2014)
    48. M. Vala, J. Homola: Flexible method based on four-beam interference lithography for fabrication of large areas of perfectly periodic plasmonic arrays, Optics Express, 22, 18778–18789 (2014).
    49. H. Šípová, T. Špringer, D. Rejman, O. Šimák, M. Petrová, P. Novák, Š. Rosenbergová, O. Páv, R. Liboska, I. Barvík, J. Štěpánek, I. Rosenberg, J. Homola: 5’-O-Methylphosphonate nucleic acids (MEPNA) – new modified DNAs that increase the E. coli RNase H cleavage rate of hybrid duplexes, Nucleic Acids Research,42, 5378–5389 (2014). link
    50. M. Kuchař, L. Vaňková, H. Petroková, J. Černý, R. Osička, H. Šípová, O. Pelák, J. Homola, B. Schneider, T. Kalina, P. Šebo, and P. Malý: Human interleukin-23 receptor antagonists derived from an albumin-binding domain scaffold inhibit IL-23-dependent ex vivo expansion of IL-17-producing T-cells, PROTEINS: Structure, Function, and Bioinformatics, 82, 975-989 (2014).
    51. A. Giorgini, S. Avino, P. Malara, R. Zullo, G. Gagliardi, J. Homola, P. De Natale: Cavity-enhanced surface-plasmon resonance sensing: modeling and performance, Measurement Science and Technology, 25, 015205 (2014).
    52. P N. Scott Lynn, J. I. Martínez-López, M. Bocková, P. Adam, V. Coello, H. R. Siller, J. Homola: Biosensing enhancement using passive mixing structures for microarray-based sensors, Biosensors and Bioelectronics, 54, 506–514 (2014).
    53. H. Vaisocherová, V. Ševců, P. Adam, B. Špačková, A. S. Pereira, C. Rodriguez-Emmenegger, T. Riedel, E. Brynda, J. Homola: Functionalized ultra-low fouling carboxy- and hydroxy-functional surface platforms and their fouling resistance from undiluted biological media and biorecognition capability, Biosensors and Bioelectronics, 51, 150–157 (2014).
    54. Y. Hee Jang, K. Chung, L. N. Quan, B. Špačková, H. Šípová, S. Moon, W. J. Cho, H. H.-Y. Shin, Y. J. Jang, J.-E. Lee, S. T. Kochuveedu, M. J. Yoon, J. Kim, S. Yoon, J. K. Kim, D. Kim, J. Homola, D. H. Kim: Configuration-controlled Au nanocluster arrays with unique plasmonic coupling property on reconstructed inverse micelle nano-patterns: versatile platforms for SERS and advanced Kretschmann-type SPR sensors, Nanoscale, 5, 12261-12271 (2013).
    55. B. Špačková, J. Homola: Sensing properties of lattice resonances: an analytical model, Optics Express, 21, 27490-27502 (2013).
    56. H. Aouani, M. Rahmani, H. Šípová, V. Torres, K. Hegnerová, M. Beruete, J. Homola, M. Hong, M. Navarro-Cía, and S. Maier: Plasmonic nanoantennas for multispectral surface-enhanced spectroscopies, Journal of Physical Chemistry C, 117, 18620–18626 (2013).
    57. Z. Krištofiková, D. Řípová, K. Hegnerová, J. Šírová, J. Homola: Protein τ-mediated effects on rat hippocampal choline transporters CHT1 and τ–amyloid β interactions, Neurochemical Research, 38, 1949–1959 (2013).
    58. T. Špringer, M. Bocková, J. Homola: Label-Free Biosensing in Complex Media: A Referencing Approach, Analytical Chemistry, 85, 5637–5640 (2013).
    59. A. Giorgini, S. Avino, P. Malara, G. Gagliardi, M. Casalino, G. Coppola, M. Iodice, P. Adam, K. Chadt, J. Homola, P. De Natale, Surface plasmon resonance optical cavity enhanced refractive index sensing, Optics Letters, 11, 1951-1953 (2013).
    60. K. Toma, M. Vala, P. Adam, J. Homola, W. Knoll and J. Dostálek: Compact surface plasmon-enhanced fluorescence biochip, Optics Express, 21, 10121-10132 (2013).
    61. H. Šípová, Homola: Surface plasmon resonance sensing of nucleic acids: a review, Analytica Chimica Acta, 773, 9–23 (2013).
    62. Z. Krištofiková, D. Řípová, A. Bartoš, M. Bocková, K. Hegnerová, J. Říčný, L. Čechová, M. Vrajová, J. Homola: Neuroinflammation and Complexes of 17β-hydroxysteroid dehydrogenase type 10 - amyloid β in Alzheimer`s disease, Current Alzheimer Research, 10, 165-173 (2013).
    63. H. Aouani, H. Šípová, M. Rahmani, M. Navarro-Cia, K. Hegnerová, J. Homola, M. Hong, S. A. Maier: Ultrasensitive broadband probing of molecular vibrational modes with multifrequency optical antennas, ACS Nano, 7, 669–675 (2013).
    64. M. Vala, R. Robelek, M. Bocková, J. Wegener, J. Homola: Real-time label-free monitoring of the cellular response to osmotic stress using conventional and long-range surface plasmons, Biosensors and Bioelectronics, 40, 417-421 (2013).
    65. T. Dar, J. Homola, B. M. Azizur Rahman and M. Rajarajan: Label-free slot-waveguide biosensor for the detection of DNA hybridisation, Applied Optics, 51, 8195–8202 (2012).
    66. T. Špringer, J. Homola: Bio-functionalized gold nanoparticles for SPR biosensor-based detection of CEA in blood plasma, Analytical and Bioanalytical Chemistry, 404, 2869-2875 (2012).
    67. H. Šípová, V. Ševců, M. Kuchař, J. N. Ahmad, P. Mikulecký, R. Osička, P. Malý, J. Homola: Surface plasmon resonance biosensor based on engineered proteins for direct detection of interferon-gamma in diluted blood plasma, Sensors and Actuators B, 174, 306–311 (2012).
    68. M. Toma, K. Toma, P. Adam, J. Homola, W. Knoll, J. Dostálek: Surface plasmon-coupled emission on plasmonic Bragg gratings, Optics Express, 20, 14042–14053 (2012).
    69. J. N. Ahmad, J. Li, L. Biedermannová, M. Kuchař, H. Šípová, A. Semerádtová, J. Černý, H. Petroková, P. Mikulecký, J. Polínek, O. Staněk, J. Vondrášek, J. Homola, J. Malý, R. Osička, P. Šebo, and P. Malý: Novel high-affinity binders of human interferon gamma derived from albumine-binding domain of protein G, PROTEINS: Structure, Function, and Bioinformatics, 80, 774–789 (2012).
    70. P. Kvasnička, K. Chadt, M. Vala, M. Bocková and J. Homola: Towards single-molecule detection with sensors based on propagating surface plasmons, Optics Letters, 37, 163–165 (2012).
    71. K. Pimková, M. Bocková, K. Hegnerová, J. Suttnar, J. Čermák, J. Homola, J. E. Dyr: Surface plasmon resonance biosensor for the detection of VEGFR-1 – a protein marker of myelodysplastic syndromes, Analytical and Bioanalytical Chemistry, 402, 381-387 (2012).
    72. H. Šípová, D. Vrba, J. Homola: Analytical value of detecting an individual molecular binding event: the case of the SPR biosensor, Analytical Chemistry, 84, 30-33 (2012).
    73. M. Piliarik, H. Šípová, P. Kvasnička, N. Galler, J. R. Krenn, J. Homola: High-resolution biosensor based on localized surface plasmons, Optics Express, 20, 672–680 (2012).
    74. J. Xu, P. Kvasnička, M. Idso, R. W. Jordan, H. Gong, J. Homola, Q. Yu: Understanding the effects of dielectric medium, substrate, and depth on electric fields and SERS of quasi-3D plasmonic nanostructures, Optics Express, 19, 20493-20505 (2011).
    75. J. Xu, P. Guan, P. Kvasnička, H. Gong, J. Homola, Q. Yu: Light transmission and surface-enhanced Raman scattering of quasi-3d plasmonic nanostructure arrays with deep and shallow Fabry-Pérot nanocavities, Journal of Physical Chemistry C, 115, 10996–11002 (2011).
    76. M. Piliarik, P. Kvasnička, N. Galler, J. R. Krenn, J. Homola: Local refractive index sensitivity of plasmonic nanoparticles, Optics Express, 19, 9213–9220 (2011).
    77. H. Vaisocherová, A. D. Taylor, S. Jiang, K. Hegnerová, M. Vala, J. Homola, B. J. Yakes, J. Deeds, S. DeGrasse: Surface plasmon resonance biosensor for determination of tetrodotoxin (TTX): pre-validation study, Journal of AOAC International, 94, 596-604 (2011).
    78. H. Šípová, T. Špringer, J. Homola: Streptavidin-enhanced assay for sensitive and specific detection of single nucleotide polymorphism in TP53, Analytical and Bioanalytical Chemistry, 399, 2343–2350 (2011).
    79. A. Friedl, P. Adam, S. Leshkov, J. Homola: Fabrication of nanoplasmonic arrays with square symmetry using spin-coating method, Journal of Nanoscience and Nanotechnology, 11, 2528-2532 (2011).
    80. J. Xu, L. Zhang, H. Gong, J. Homola, Q. Yu: Tailoring plasmonic nanostructures for optimal SERS sensing of small molecules and large microorganisms, Small, 7, 371–376 (2011).
    81. H. Šípová, S. Zhang, A. M. Dudley, D. Galas, K. Wang, J. Homola: Surface plasmon resonance biosensor for rapid label-free detection of microRNA at subfemtomole level, Analytical Chemistry, 82, 10110–10115 (2010).
    82. M. Piliarik, M. Bocková, J. Homola: Surface plasmon resonance biosensor for parallelized detection of protein biomarkers in blood plasma, Biosensors and Bioelectronics, 26, 1656–1661 (2010).
    83. H. Šípová, H. Vaisocherová, J. Štěpánek, J. Homola: A Two-level surface plasmon resonance assay for determination of Ribonuclease H activity, Biosensors and Bioelectronics, 26, 1605–1611(2010).
    84. F. Fernández, K. Hegnerová, M. Piliarik, F. S. Baeza, J. Homola, M.-Pilar Marco: A label-free and portable multichannel surface plasmon resonance immunosensor for on site analysis of antibiotics in milk samples, Biosensors and Bioelectronics, 26, 1231–1238 (2010).
    85. T. Špringer, H. Šípová, H. Vaisocherová, J. Štěpánek, J. Homola: Shielding effect of monovalent and divalent cations on closely packed oligonucleotides, Nucleic Acids Research, 38, 7343–7351 (2010).
    86. K. Hegnerová, J. Homola: Surface plasmon resonance sensor for detection of bisphenol A in drinking water, Sensors and Actuators B, 151, 177-179 (2010).
    87. S. Herranz, M. Bocková, M. D. Marazuela, J. Homola, M. C. Moreno-Bondi: An SPR biosensor for the detection of microcystins in drinking water, Analytical and Bioanalytical Chemistry, 398, 2625–2634 (2010).
    88. T. Špringer, M. Piliarik, J. Homola: Real-time monitoring of biomolecular interactions in blood plasma using a surface plasmon resonance biosensor, Analytical and Bioanalytical Chemistry, 398, 1955–1961 (2010).
    89. K. Hegnerová, M. Piliarik, M. Šteinbachová, Z. Flegelová, H. Černohorská, J. Homola: Detection of bisphenol A using a novel surface plasmon resonance biosensor, Analytical and Bioanalytical Chemistry, 398, 1963–1966 (2010).
    90. M. Vala, K. Chadt, M. Piliarik, J. Homola: High-performance compact SPR sensor for multi-analyte sensing, Sensors and Actuators B, 148, 544-549 (2010).
    91. N. D. Brault, C. Gao, H. Xue, M. Piliarik, J. Homola, S. Jiang, Q. Yu: Ultra-low fouling and functionalizable zwitterionic coatings grafted onto SiO2 via a biomimetic adhesive group for sensing and detection in complex media, Biosensors and Bioelectronics, 25, 2276–2282 (2010).
    92. T. Špringer, M. Piliarik, J. Homola: Surface plasmon resonance sensor with dispersionless microfluidics for direct detection of nucleic acids at the low femtomole level, Sensors and Actuators B, 145, 588-591 (2010).
    93. B. Špačková, J. Homola: Theoretical analysis of a fiber optic surface plasmon resonance sensor utilizing a Bragg grating, Optics Express, 17, 23254–23264 (2009).
    94. Z. Krištofiková, M.Bocková, K.Hegnerová, A. Bartoš, J. Klaschka, J.Říčný, D. Řípová, J.Homola, Enhanced levels of mitochondrial enzyme 17ß-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosis, Molecular Biosystems, 5, 1174 – 1179 (2009).
    95. M. Piliarik; J. Homola: Surface plasmon resonance (SPR) sensors: approaching their limits?, Optics Express, 17, 16505-16517 (2009).
    96. M. Piliarik; M. Vala; I. Tichý; J. Homola: Compact and low-cost biosensor based on novel approach to spectroscopy of surface plasmons, Biosensors & Bioelectronics, 24 3430–3435 (2009).
    97. B. Špačková, M. Piliarik, P. Kvasnička, C. Themistos, M. Rajarajan, J. Homola: Novel concept of multi-channel fiber optic surface plasmon resonance sensor, Sensors and Actuators B, 139, 199–203 (2009).
    98. K. Hegnerová, M. Bocková, H. Vaisocherová, Z. Krištofiková, J.Říčný, D. Řípová, J. Homola: Surface plasmon resonance biosensors for detection of Alzheimer disease biomarkers, Sensors and Actuators B, 139, 69–73 (2009).
    99. M. Vala, S. Etheridge, J.A. Roach, J. Homola: Long-range surface plasmons for sensitive detection of bacterial analytes, Sensors and Actuators B, 139, 59–63 (2009).
    100. M. Rajarajan, T. Dar, C. Themistos, B.M.A. Rahman, K.T.V. Grattan, J. Homola, J. Irudayaraj, Modeling and characterization of surface plasmon based sensors for the detection of E coli, Journal of Modern Optics, 56, 564 – 571 (2009).
    101. H. Vaisocherová, Z. Zhang, W. Yang, Z. Cao, G. Cheng, A. D Taylor, M. Piliarik, J. Homola, S. Jiang: Functionalizable surface platform with reduced nonspecific protein adsorption from full blood plasma - material selection, protein immobilization optimization, Biosensors & Bioelectronics, 24, 1924-1930 (2009).
    102. H. Vaisocherová, J. Snášel, T. Špringer, H. Šípová, I. Rosenberg, J. Štěpánek, J. Homola: Surface plasmon resonance study on HIV-1 integrase strand transfer activity, Analytical and Bioanalytical Chemistry, 393, 1165-1172 (2009).
    103. J. Ladd, T. Allen, M. Piliarik, J. Homola, S. Jiang: Label-free detection of cancer biomarker candidates using surface plasmon resonance imaging, Analytical and Bioanalytical Chemistry, 393, 1157-1163 (2009).
    104. M. Piliarik, L. Párová, J. Homola: High-throughput SPR sensor for food safety, Biosensors & Bioelectronics, 24, 1399-1404 (2009).
    105. P. Kvasnička, J. Homola: Optical sensors based on spectroscopy of localized surface plasmons on metallic nanoparticles: sensitivity considerations, Biointerphases, 3, FD4-FD11 (2008).
    106. H. Vaisocherová, W. Yang, Z. Zhang, Z. Cao, G. Cheng, M. Piliarik, J. Homola, S. Jiang: Utra-low fouling and functionalizable surface chemistry based on a zwitterionic polymer enabling sensitive and specific protein detection in undiluted blood plasma, Analytical Chemistry, 80, 7894–7901 (2008).
    107. M. Piliarik, J. Homola: Self-referencing SPR imaging for most demanding high throughput screening applications, Sensors and Actuators B, 134, 353–355 (2008).
    108. Z. Hlavenková, J. Homola: Comparative surface plasmon spectroscopy for characterization of thin films, Electronics Letters, 44, 1085-1087 (2008).
    109. Z. Krištofiková, K. Hegnerová, M. Bocková, H. Vaisocherová, A. Bartoš, J.Říčný, D. Řípová, J. Homola: Analysis of the complex between amyloid beta peptides and mitochondrial enzyme 17beta-HSD in cerebrospinal fluid, FEBS Journal, 275, 249-249, Suppl. 1 (2008).
    110. V. Ostatná, H. Vaisocherová, J. Homola, T. Hianik: Effect of the immobilisation of DNA aptamers on the detection of thrombin by means of surface plasmon resonance, Analytical and Bioanalytical Chemistry, 391, 1861–1869 (2008).
    111. J. Ladd, T. Allen, M. Piliarik, J. Homola, S. Jiang: Hybrid surface platform for the simultaneous detection of proteins and DNA using a surface plasmon resonance (SPR) imaging sensor, Analytical Chemistry, 80, 4231-4236 (2008).
    112. J. Homola: Surface plasmon resonance sensors for detection of chemical and biological species, Chemical Reviews, 108, 462-493 (2008).
    113. J. Ladd, A. D. Taylor, J. Homola, S. Jiang: Detection of botulinum neurotoxins in buffer and honey using a surface plasmon resonance (SPR) sensor, Sensors and Actuators B, 130, 129-134 (2008).
    114. J. Dostálek, J. Homola: Surface plasmon resonance sensor based on an array of diffraction gratings for highly-parallelized observation of biomolecular interactions, Sensors and Actuators B, 129, 303-310 (2008).
    115. J. Dostálek, J. Přibyl, J. Homola, P. Skládal: Multichannel SPR biosensor for detection of endocrine disrupting compounds, Analytical and Bioanalytical Chemistry, 389, 1841–1847 (2007).
    116. J. Dostálek, P. Adam, P. Kvasnička, O. Telezhnikova, J. Homola: Spectroscopy of Bragg-scattered surface plasmons for characterization of thin biomolecular films, Optics Letters, 32, 2903-2905 (2007).
    117. P. Křížová, L. Mášová, J. Suttnar, P. Salaj, J. E. Dyr, J. Homola, M. Pecka: The influence of intrinsic coagulation pathway on blood platelets activation by oxidized cellulose, Journal of Biomedical Materials Research A, 82 A, 274-280 (2007).
    118. R. Slavík, J. Homola: Ultrahigh resolution long range surface plasmon-based sensor, Sensors and Actuators B, 123, 10-12 (2007).
    119. M. Piliarik, H. Vaisocherová, and J. Homola: Towards parallelized surface plasmon resonance sensor platform for sensitive detection of oligonucleotides, Sensors and Actuators B, 121, 187-193 (2007).
    120. H. Vaisocherová, K. Mrkvová, M. Piliarik, P. Jinoch, M. Šteinbachová, and J. Homola: Surface plasmon resonance biosensor for direct detection of antibody against Epstein-Barr virus, Biosensors & Bioelectronics, 22, 1020-1026 (2007).
    121. A. D. Taylor, J. Ladd, Q. Yu, S. Chen, J. Homola, and S. Jiang: Quantitative and simultaneous detection of four foodborne bacterial pathogens with a multi-channel SPR sensor, Biosensors & Bioelectronics, 22 752-758 (2006).
    122. O. Telezhnikova, J. Homola: A new approach to spectroscopy of surface plasmons, Optics Letters, 31, 3339-3341 (2006).
    123. H. Vaisocherová, A. Zítová, M. Lachmanová, J. Štěpánek, S. Králíková, R. Liboska, D. Rejman, I. Rosenberg, and J. Homola: Investigating oligonucleotide interactions at subnanomolar level by surface plasmon resonance biosensor, Biopolymers, 82, 394–398 (2006).
    124. R. Slavík, J. Homola: Optical multilayers for LED-based surface plasmon resonance sensors, Applied Optics, 45, 3752-3759 (2006).
    125. R. Slavík, J. Homola, and H. Vaisocherová: Advanced biosensing using simultaneous excitation of short and long range surface plasmons, Measurement Science and Technology, 17, 932-938 (2006).
    126. R. Slavík, J. Homola: Simultaneous excitation of long and short -range surface plasmons in an asymmetric structure, Optics Communications, 259, 507-512 (2006).
    127. P. Adam, J. Dostálek, J. Homola: Multiple surface plasmon spectroscopy for study of biomolecular systems, Sensors and Actuators B, 113, 774-781 (2006).
    128. J. Homola, H. Vaisocherová, J. Dostálek, M. Piliarik: Multi-analyte surface plasmon resonance biosensing, Methods, 37, 26-36 (2005).
    129. J. Dostálek, H. Vaisocherová, J. Homola: Multichannel surface plasmon resonance biosensor with wavelength division multiplexing, Sensors and Actuators B, 108, 758-764 (2005).
    130. A. D. Taylor, Q. Yu, S. Chen, J. Homola, and S. Jiang: Comparison of E. coli O157:H7 preparation methods used for detection with surface plasmon resonance sensor, Sensors and Actuators B, 107, 202-208 (2005).
    131. Q. Yu, S. Chen, A. Taylor, J. Homola, B Hock, and S. Jiang: Detection of low-molecular-weight domoic acid using surface plasmon resonance sensor, Sensors and Actuators B, 107, 193-201 (2005).
    132. P. Tobiška, J. Homola: Advanced data processing for SPR biosensors, Sensors and Actuators B, 107, 162-169 (2005).
    133. J. Dostálek, J. Homola, M. Miler: Rich information format surface plasmon resonance biosensor based on array of diffraction gratings, Sensors and Actuators B, 107, 154-161(2005).
    134. M. Piliarik, H. Vaisocherová and J. Homola: A new surface plasmon resonance sensor for high-throughput screening applications, Biosensors and Bioelectronics, 20, 2104-2110 (2005).
    135. C. Boozer, J. Ladd, S. Chen, Q. Yu, J. Homola, and S. Jiang: DNA directed protein immobilization on mixed ssDNA/Oligo(ethylene glycol) self-assembled monolayers for sensitive biosensors, Analytical Chemistry, 76, 6967-6972 (2004).
    136. J. Ladd, C. Boozer, Q. Yu, S. Chen, J. Homola, S. Jiang: DNA-directed protein immobilization on mixed self-assembled monolayers via a streptavidin bridge, Langmuir, 20, 8090-8095 (2004).
    137. J. Homola: Present and future of surface plasmon resonance biosensors, Analytical and Bioanalytical Chemistry, 377, 528-539 (2003).
    138. J. Ryšavá, J. E. Dyr, J. Homola, J. Dostálek, P. Křížová, L. Mášová, J. Suttnar, J. Briestenský, I. Santar, K. Myška, M. Pecka, Surface interactions of oxidized cellulose with fibrin(ogen) and blood platelets, Sensors and Actuators B, 90, 243-249 (2003).
    139. M. Piliarik, J. Homola, Z. Maníková, J. Čtyroký, Surface plasmon resonance sensor based on a single-mode polarization-maintaining optical fiber, Sensors and Actuators B, 90, 236-242 (2003).
    140. C. Boozer, Q. Yu, S. Chen, C. Y. Lee, J. Homola, S.Yee, S. Jiang, Surface functionalization for self-referencing surface plasmon resonance (SPR) biosensors by multi-step self assembly, Sensors and Actuators B, 90, 22-30 (2003).
    141. G. G. Nenninger, M. Piliarik, J. Homola: Data analysis for optical sensors based on spectroscopy of surface plasmons, Measurement Science and Technology, 13, 2038-2046 (2002).
    142. S. Chen, L. Li, C. L. Boozer, J. Homola, S. S. Yee, S. Jiang: Detecting the adsorption of dye molecules in homogenous poly(propylene imine) dendrimer monolayers by surface plasmon resonance sensor, Journal of American Chemical Society, 124, 3395-3401 (2002).
    143. R. Slavík, J. Homola, E. Brynda: A miniature fiber optic surface plasmon resonance sensor for fast detection of staphylococcal enterotoxin B, Biosensors and Bioelectronics, 17, 591-595 (2002).
    144. J. Homola, J. Dostálek, S. Chen, A. Rasooly, S. Jiang, S. S. Yee: Spectral surface plasmon resonance biosensor for detection of staphylococcal enterotoxin B (SEB) in milk, International Journal of Food Microbiology, 75, 61-69 (2002).
    145. J. Dostálek, J. Čtyroký, J. Homola, E. Brynda, M. Skalský, P. Nekvindová, J. Špirková, J. Škvor, J. Schröfel: Surface plasmon resonance biosensor based on integrated optical waveguide, Sensors and Actuators, 76, 8-12 (2001).
    146. J. Homola, H. B. Lu, G. G. Nenninger J. Dostálek, S. S. Yee: A novel multichannel surface plasmon resonance biosensor, Sensors and Actuators, 76, 403-410 (2001).
    147. H. B. Lu, J. Homola, C. T. Campbell, G. G. Nenninger, S. S. Yee, B. D. Ratner: Protein contact printing for a surface plasmon resonance biosensor with on-chip referencing, Sensors and Actuators 74, 91-99 (2001).
    148. V. Koubová, E. Brynda, L. Karasová, J. Škvor, J. Homola, J. Dostálek, P. Tobiška, J. Rošický: Detection of foodborne pathogens using surface plasmon resonance biosensors, Sensors and Actuators 74, 100-105 (2001).
    149. G. G. Nenninger, P. Tobiška, J. Homola, S. S. Yee: Long-range surface plasmons for high-resolution surface plasmon resonance sensors, Sensors and Actuators 74, 145-151 (2001).
    150. R. Slavík, J. Homola, J. Čtyroký: Novel spectral fiber optic sensor based on surface plasmon resonance, Sensors and Actuators 74, 106-111 (2001).
    151. J. E. Dyr, J. Ryšavá, J. Suttnar, J. Homola, P. Tobiška, Optical sensing of the initial stages in the growth and development of fibrin clot, Sensors and Actuators 74, 69-73 (2001).
    152. J. Ryšavá, J.E.Dyr, J.Suttnar, P.Cieslar, E.Brynda, M. Houska, A. Brandenburg, J. Homola: Thrombogenicity of fibrinogen layers, Chemické listy 8, 565 (2000).
    153. J. Homola, H. B. Lu, S. S. Yee: Dual-channel surface plasmon resonance sensor with spectral discrimination of sensing channels using a dielectric overlayer, Electronics Letters 35, 1105-1106 (1999).
    154. J. Homola, S. Yee, G. Gauglitz: Surface plasmon resonance sensors: review, Sensors and Actuators B 54, 3-15 (1999).
    155. J. Homola, I. Koudela, S. Yee: Surface plasmon resonance sensors based on diffraction gratings and prism couplers: sensitivity comparison, Sensors and Actuators B 54, 16-24 (1999).
    156. J. Čtyroký, J. Homola, P. V. Lambeck, S. Musa, H. J. W. M. Hoekstra, R. D. Harris, J. S. Wilkinson, B. Usievich, N. M. Lyndin: Theory and modeling of optical waveguide sensors utilizing surface plasmon resonance, Sensors and Actuators B 54, 66-73 (1999).
    157. E. Brynda, J. Homola, M. Houska, P. Pfeifer, J. Škvor: Antibody networks for surface plasmon resonance immunosensors, Sensors and Actuators B 54, 132-136 (1999).
    158. R. Slavík, J. Homola, J. Čtyroký: Single-mode optical fiber surface plasmon resonance sensor, Sensors and Actuators B 54, 74-79 (1999).
    159. J. E. Dyr, I. Tichý, M. Jiroušková, P. Tobiška, R. Slavík, J. Homola, J. Suttnar: Real-time sensing of surface-bound fibrinogen and fibrin interactions using spectroscopy of guided modes in optical waveguide structures, surface plasmon resonance, and specific monoclonal antibodies, Blood Coagulation and Fibrinolysis 9, 675 (1998).
    160. J. E. Dyr, I. Tichý, M. Jiroušková, P. Tobiška, R. Slavík, J. Homola, E. Brynda, M. Houska, J. Suttnar: Molecular arrangement of adsorbed fibrinogen molecules characterized by specific monoclonal antibodies and a surface plasmon resonance sensor, Sensors and Actuators B 51, 268-272 (1998).
    161. R. Slavík, J. Homola, J. Čtyroký: Miniaturization of fiber optic surface plasmon resonance sensor, Sensors and Actuators B 51, 311-315 (1998).
    162. N. Scott Lynn Jr., H. Šípová, P. Adam, J. Homola: Enhancement of affinity-based biosensors: effect of sensing chamber geometry on sensitivity, Lab on a Chip, 13, 1413 – 1421 (2013).
    163. J. Homola, S. S. Yee: Novel polarization control scheme for spectral surface plasmon resonance sensors, Sensors and Actuators B 51, 331-339 (1998).
    164. J. Čtyroký, J. Homola, M. Skalský: Tuning of spectral operation range of a waveguide surface plasmon resonance sensor, Electronics Letters 33, 1246 - 1248 (1997).
    165. J. Homola, R. Slavík, J. Čtyroký: Interaction between fiber modes and surface plasmon waves: spectral properties, Optics Letters 22, 1403 - 1405 (1997).
    166. J. Čtyroký, J. Homola, M. Skalský: Modeling of surface plasmon resonance waveguide sensor by complex mode expansion and propagation method, Optical and Quantum Electronics 29, 301 - 311 (1997).
    167. J. Homola, J. Čtyroký, M. Skalský, J. Hradilová, P. Kolářová: A surface plasmon resonance based integrated optical sensor, Sensors and Actuators B 38 - 39, 286 - 290 (1997).
    168. J. Homola: On the sensitivity of surface plasmon resonance sensors with spectral interrogation, Sensors and Actuators B 41, 207 - 211 (1997).
    169. J. Homola, S. S. Yee: Surface plasmon resonance sensor based on planar light pipe: theoretical optimization analysis, Sensors and Actuators B 37, 145 - 150 (1996).
    170. J. Homola, R. Slavík: Fiber-optic sensor based on surface plasmon resonance, Electronics Letters 32, 480 - 482 (1996).
    171. J. Homola: Optical fiber sensor based on surface plasmon excitation, Sensors and Actuators B 29, 401 - 405 (1995).
    172. J. Homola: Model of a chemooptical sensor based on surface plasmon excitation in thin silver films, Sensors and Actuators B 11, 481 - 485 (1993).

     

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