Externí odkazy

Modely neinvazivní mozkové stimulace

2023 - 2024

Transcranial magnetic stimulation (TMS) is a tool that is used regularly in experimental and clinical research, as well as for therapeutic and diagnostic purposes. Yet, little is known about the detailed processes that lead to the nervous and muscular responses. This causes considerable uncertainty in the interpretation of results, and large interindividual variability in treatment effectiveness. The goal of this interdisciplinary project is to create a computational model of nerve and muscle activity in response to TMS, which synthesises current models for the conversion of electromagnetic fields to nervous activity (expertise of Leipzig), and the propagation of activity in the central and peripheral nervous system (expertise of Prague). This will be achieved by simulating the complete communication pathway from neuronal activity in cortex, to motor evoked potentials (MEP) in the muscular periphery. The resulting model will be calibrated with existing data (Leipzig), and be subjected to detailed parameter studies with the aim to improve the use of TMS as a diagnostic tool.