| Abstract |
In connection with novel nucleoside cytostatics developed in our laboratory, the topic of this project will be the design and synthesis of new substituted and annulated purine nad deazapurine nucleosides. Transition metal catalyzed cross-coupling reactions, C-H activations and heterocyclizations will be the methods of choice in the synthesis of the target compounds. The nucleosides will be tested on cytostatic activity in collaboration with Gilead Sciences Inc. and University Hospital Olomouc. The project will rely mainly on organic synthesis but partly also on methodologies of racional drug design. |
