Landa P., Kokoska L., Pribylova M., Vanek T., Marsik P.
32 [1]:
75-78,
2009
Klíčová slova:
Carvacrol; Cyclooxygenase; Prostaglandin; Inhibition; Anti-inflammatory
Abstrakt:
Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E-2 catalysed by COX-2 with an IC50 value of 0.8 mu M what is practically the same concentration as the IC50 obtained for the standard inhibitors indomethacin and NS-398 with values of 0.7 mu M and 0.8 mu M, respectively. The COX-1 was inhibited approximately at the same rate (IC50 of 0.7 mu M for carvacrol), which suggests non-selective inhibition of both enzyme isoforms. The results of the study demonstrate possible anti-inflammatory potential of this compound due to the inhibition of inducible COX-2 isoform.
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Autoři z ÚEB: Přemysl Landa,
Petr Maršík,
Marie Přibylová,
Tomáš Vaněk