Research topics
Molecular mechanisms of cell fate determination and differentiation in multipotential haematopoietic and neural cells and precursors of muscle cells. Molecular mechanisms of malignant transformation of myeloid cells, melanocytes and nephrogenic blastema. Molecular mechanisms of photoinduced apoptosis in tumour cells and targeted drug delivery into tumour tissues
Current Grant Support
Ministry of Education, Youth and Sports of the Czech Republic (Center of Cell Invasiveness in Embryonic Development and Tumour Metastases, grant No.: LC06061; Center of Chemical Genetics, grant No.: LC06077); Grant Agency of the Czech Republic (grants Nos. 204/06/1728, 203/06/1038); Academy of Sciences of the Czech Republic (grants Nos. AV0Z50520514, IAA500520608, project KAN200200651)
Most important recent papers
(2002-present; names of the lab members underlined)Kralova, J., Liss, A. S., Bargmann, W., Pendleton, C., Varadarajan, J., Ulug, E., Bose, H. R., Jr.: AP-1 factors play an important role in transformation induced by the v-rel oncogene. J. Virol. 76: 11960-11970, 2002. (PubMed)
Bartunek, P., Pajer, P., Karafiat, V., Blendinger, G., Dvorak, M., Zenke, M.: bFGF signaling and v-Myb cooperate in sustained growth of primitive erythroid progenitors. Oncogene 21: 400-410, 2002. (PubMed)
Pajer, P., Pecenka, V., Karafiat, V., Kralova, J., Horejsi, Z., Dvorak, M.: The twist gene is a common target of retroviral integration and transcriptional deregulation in experimental nephroblastoma. Oncogene 22: 665-673, 2003. (PubMed)
Kralova, J., Dvorak, M., Kral, V.: Novel cationic transport agents for oligonucleotide delivery into primary leukemic cells J. Med. Chem. 46: 2049-2056, 2003. (PubMed)
Kaspar, P., Pajer, P., Sedlak, D., Tamaoki, T., Dvorak, M.: c-Myb inhibits myogenic differentiation through repression of MyoD. Exp. Cell Res. 309: 419-428, 2005. (PubMed)
Karafiat, V., Dvorakova, M., Krejci, E., Kralova, J., Pajer, P., Snajdr, P., Mandikova, S., Bartunek, P., Grim, M., Dvorak, M.: Transcription factor c-Myb s involved in the regulation of the epitelial-mesenchymal transition in the avian neural crest.Cell Mol. Life Sci. 62: 2516-2525, 2005. (PubMed)
Kral, V., Lang, K., Kralova, J., Dvorak, M., Martasek, P., Chin, A. O., Andrievsky, A., Lynch, V., Sessler, J. L.: Polyhydroxylated sapphyrins: multisite non-metallic catalysts for activated phosphodiester hydrolysis. J. Am. Chem. Soc. 128: 432-437, 2006. (PubMed)
Pajer, P., Pecenka, V., Kralova, J., Karafiat, V., Prukova, D., Zemanova, Z., Kodet, R., Dvorak, M.: Identification of potential human oncogenes by mapping the common viral integration sites in avian nephroblastoma. Cancer Res. 66: 78-86, 2006. (PubMed)
Nanka, O., Valasek, P., Dvorakova, M., Grim, M.: Experimental hypoxia and embryonic angiogenesis. Dev Dyn. 235: 723-733, 2006. (PubMed)
Karafiat, V., Dvorakova, M., Pajer, P., Cermak, V., Dvorak, M.: Melanocyte fate in neural crest is triggered by Myb proteins through activation of c-kit. Cell Mol Life Sci. 64: 2975-84, 2007. (PubMed)
Bartunek, P., Karafiat, V., Bartunkova, J., Pajer, P., Dvorakova, M., Kralova, J., Zenke, M., Dvorak, M.: Impact of chicken thrombopoietin and its receptor c-Mpl on hematopoietic cell development. Exp Hematol. 36: 495-505, 2008. (PubMed)
Kralova, J., Dvorak, M., Koc, M., Kral, V.: p38 MAPK plays an essential role in apoptosis induced by photoactivation of a novel ethylene glycol porphyrin derivative. Oncogene. 27: 3010-20, 2008. (PubMed)
Kaspar, P., Dvorak, M.: Involvement of phosphatidylserine externalization in the down-regulation of c-myb expression in differentiating C2C12 cells. Differentiation. 76: 245-52, 2008. (PubMed)
Kralova, J., Briza, T., Moserova, I., Dolensky, B., Vasek, P., Pouckova, P., Kejik, Z., Kaplanek, R., Martasek, P., Dvorak, M., and Kral, V.: Glycol-porphyrin derivatives as potent photodynamic inducers of apoptosis in tumor cells. J Med Chem. 51: 5964-73, 2008. (PubMed)
Other results
Application of novel bis-cyclodextrin tetrakis (pentafluorophenyl) porphyrin in the experimental tumour model for photodynamic therapy.
J. Kral (DOC) (PDF)